Yang Huaichun, Liu Hongyu, Huang Ben, Zhang Haodong, Zhu Xiaoyue, Chen Kang, Shen Jie, Qu Yanping
Department of Rehabilitation Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Rehabilitation Medicine, Shanghai Eighth People's Hospital, Shanghai, China.
Medicine (Baltimore). 2025 Jul 18;104(29):e43343. doi: 10.1097/MD.0000000000043343.
The present study aimed to investigate whether the combination of low-intensity pulsed ultrasound (LIPUS) and aerobic exercise (AE) exerts an enhanced therapeutic benefit for patients with knee osteoarthritis.
Participants were allocated into a LIPUS treatment group, an AE treatment group, and a LIPUS combined with AE (LIPUS + AE) treatment group. Numerical rating scale (NRS) and Lequesne index were determined, and gait analysis was performed before treatment and after 12 weeks of treatment.
The LIPUS treatment could significantly alleviate NRS score and Lequesne index in patients with knee osteoarthritis. The AE treatment could significantly alleviate NRS score and Lequesne index, accompanied by improvement in stride length, stride speed, and total walking distance. LIPUS + AE treatment further contributed to an improvement in NRS score and Lequesne index, accompanied by improvement in stride length, stride speed, and total walking distance. At the end of treatment, the Lequesne index improvement on LIPUS + AE treatment group was greater than LIPUS or AE group, NRS score improvement on LIPUS + AE treatment group was greater than LIPUS group. The stride speed, stride length, and total walking distance improvements on LIPUS + AE treatment group were greater than either LIPUS or AE group.
The study indicates LIPUS + AE treatment is more effective than LIPUS or AE for knee osteoarthritis. LIPUS + AE promises to be a potential rehabilitation therapy for patients with knee osteoarthritis.
本研究旨在调查低强度脉冲超声（LIPUS）与有氧运动（AE）联合应用是否能为膝骨关节炎患者带来更大的治疗益处。
将参与者分为LIPUS治疗组、AE治疗组和LIPUS联合AE（LIPUS+AE）治疗组。在治疗前和治疗12周后测定数字评定量表（NRS）和Lequesne指数，并进行步态分析。
LIPUS治疗可显著减轻膝骨关节炎患者的NRS评分和Lequesne指数。AE治疗可显著减轻NRS评分和Lequesne指数，同时步长、步速和总步行距离有所改善。LIPUS+AE治疗进一步改善了NRS评分和Lequesne指数，同时步长、步速和总步行距离也有所改善。治疗结束时，LIPUS+AE治疗组的Lequesne指数改善程度大于LIPUS组或AE组，NRS评分改善程度大于LIPUS组。LIPUS+AE治疗组的步速、步长和总步行距离改善程度大于LIPUS组或AE组。
该研究表明，LIPUS+AE治疗对膝骨关节炎的疗效优于LIPUS或AE治疗。LIPUS+AE有望成为膝骨关节炎患者的一种潜在康复治疗方法。
