Qin Hao
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
World J Gastrointest Oncol. 2025 Jul 15;17(7):105034. doi: 10.4251/wjgo.v17.i7.105034.
Pancreatic cancer is a highly aggressive malignancy with a poor prognosis and limited therapeutic options. The tumor microenvironment (TME), including cancer-associated fibroblasts (CAFs), plays a pivotal role in tumor progression and therapy resistance. Senescent CAFs, which exhibit a senescence-associated secretory phenotype (SASP), further exacerbate cancer growth through inflammatory cytokine secretion. This editorial highlights a study by Jiang , which investigates the potential of resveratrol, a natural polyphenolic compound, in targeting senescent CAFs to inhibit pancreatic cancer progression. The study demonstrates that resveratrol reduces senescent CAFs and downregulates SASP factors, thereby disrupting the pro-tumorigenic activities of these cells. Resveratrol's ability to modulate the TME, induce apoptosis in pancreatic cancer cells, and inhibit metastasis underscores its potential as an adjunctive therapy. This research offers promising insights into novel strategies for improving therapeutic outcomes in pancreatic cancer by targeting the TME and senescent CAFs.
胰腺癌是一种侵袭性很强的恶性肿瘤，预后较差，治疗选择有限。肿瘤微环境（TME），包括癌症相关成纤维细胞（CAFs），在肿瘤进展和治疗抗性中起关键作用。衰老的CAFs表现出衰老相关分泌表型（SASP），通过分泌炎性细胞因子进一步加剧癌症生长。这篇社论重点介绍了Jiang的一项研究，该研究探讨了天然多酚化合物白藜芦醇靶向衰老CAFs以抑制胰腺癌进展的潜力。该研究表明，白藜芦醇可减少衰老的CAFs并下调SASP因子，从而破坏这些细胞的促肿瘤活性。白藜芦醇调节TME、诱导胰腺癌细胞凋亡和抑制转移的能力突出了其作为辅助治疗的潜力。这项研究为通过靶向TME和衰老CAFs改善胰腺癌治疗结果的新策略提供了有前景的见解。
