Ridge Katie, Moran Barry, Little Mark A, O'Farrelly Cliona, Dunne Jean, Clowry Julianne, Loftus Clodagh, Finlay Conor M, Irvine Alan D, Conlon Niall
UCARE Centre, Clinical and Diagnostic Immunology, St. James's Hospital, Dublin, Ireland.
Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
JID Innov. 2025 Jun 20;5(5):100390. doi: 10.1016/j.xjidi.2025.100390. eCollection 2025 Sep.
Chronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a contributory role in a disease largely driven by T helper 2 polarization. Despite this, the role of mast cells in AD is important, given their release of proinflammatory mediators. Recently, myeloid and mast cell progenitors were identified as potential biomarkers for treatment response in chronic spontaneous urticaria. These LinCD117CD34FceRI cells appear to have increased egress from the bone marrow in atopy. We measured LinCD117CD34FceRI cells in the peripheral blood of 10 individuals with AD and 10 healthy controls. Flow cytometry revealed a significant increase in myeloid progenitors in participants with AD ( = .0067). Total serum IgE levels did not correlate with myeloid progenitors. To our knowledge, examination of this cell type in AD is previously unreported. Our findings suggest increased progenitor egress from the bone marrow in these patients and a possible role for myeloid progenitors in disease pathogenesis.
慢性自发性荨麻疹和特应性皮炎（AD）是伴有瘙痒症状的慢性皮肤疾病。虽然肥大细胞在慢性自发性荨麻疹的发病机制中发挥着不可或缺的作用，但其在特应性皮炎中的作用尚不清楚，在主要由辅助性T细胞2极化驱动的疾病中起促成作用。尽管如此，鉴于肥大细胞释放促炎介质，其在特应性皮炎中的作用仍很重要。最近，髓系和肥大细胞祖细胞被确定为慢性自发性荨麻疹治疗反应的潜在生物标志物。这些LinCD117CD34FceRI细胞似乎在特应性疾病中从骨髓中流出增加。我们测量了10名特应性皮炎患者和10名健康对照者外周血中的LinCD117CD34FceRI细胞。流式细胞术显示特应性皮炎患者的髓系祖细胞显著增加（P = 0.0067）。总血清IgE水平与髓系祖细胞无关。据我们所知，此前尚未报道过对特应性皮炎中这种细胞类型的检测。我们的研究结果表明，这些患者骨髓中祖细胞流出增加，并且髓系祖细胞在疾病发病机制中可能发挥作用。
