Wang Jin, Han Shumei, Mou Dapeng, Tang Xin, Shi Danli, He Mingguang, Guo Chunyan, Wang Ningli, Zhang Ye
Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and, Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Institute of Ophthalmology, Beijing, China.
Ophthalmol Sci. 2025 Jun 9;5(6):100848. doi: 10.1016/j.xops.2025.100848. eCollection 2025 Nov-Dec.
To evaluate retinal vascular parameters across primary angle-closure disease (PACD) stages and explore their association with glaucomatous optic neuropathy (GON).
A cross-sectional, hospital-based study.
We enrolled 638 eyes from 425 participants aged ≥40 years with PACD and further classified them into primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG) groups.
Retinal vascular parameters were measured using the Retinal-based Microvascular Health Assessment System and compared between 3 groups. A multivariable logistic mixed effects model was used to identify factors associated with the presence of GON.
Vessel caliber, tortuosity, complexity, and branching angle parameters.
No significant differences in retinal vascular parameters were found between PACS and PAC groups. Eyes in PACG showed significant vascular changes compared to PACS ( < 0.05). Elevated intraocular pressure (odds ratio [OR] = 2.44, < 0.001), reduced arteriolar curve tortuosity (OR = 0.12, = 0.002), arteriolar fractal dimension (OR = 0.08, = 0.027), arteriolar branching angle (OR = 0.16, = 0.004), and asymmetry ratio (OR = 0.10, < 0.001 for artery and OR = 0.25, = 0.023 for vein) were significantly associated with the presence of GON.
Retinal "vascular geometric fingerprints" show significant alterations in eyes with PACG compared to PACS and are independently associated with the presence of GON. These findings offer new insights into the vascular changes in GON, and longitudinal studies are needed to determine their prognostic value and clinical utility in managing PACD.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
评估原发性闭角型青光眼（PACD）各阶段的视网膜血管参数，并探讨其与青光眼性视神经病变（GON）的关联。
一项基于医院的横断面研究。
我们纳入了425名年龄≥40岁的PACD患者的638只眼睛，并将其进一步分为原发性闭角型青光眼可疑（PACS）、原发性闭角型青光眼（PAC）和原发性闭角型青光眼（PACG）组。
使用基于视网膜的微血管健康评估系统测量视网膜血管参数，并在三组之间进行比较。采用多变量逻辑混合效应模型来确定与GON存在相关的因素。
血管管径、迂曲度、复杂性和分支角度参数。
PACS组和PAC组之间的视网膜血管参数无显著差异。与PACS组相比，PACG组的眼睛显示出明显的血管变化（<0.05）。眼压升高（比值比[OR]=2.44，<0.001）、小动脉曲线迂曲度降低（OR=0.12，=0.002）、小动脉分形维数（OR=0.08，=0.027）、小动脉分支角度（OR=0.16，=0.004）和不对称率（动脉OR=0.10，<0.001；静脉OR=0.25，=0.023）与GON的存在显著相关。
与PACS组相比，PACG组眼睛的视网膜“血管几何指纹”显示出显著改变，并且与GON的存在独立相关。这些发现为GON中的血管变化提供了新的见解，需要进行纵向研究以确定它们在管理PACD中的预后价值和临床实用性。
作者对本文讨论的任何材料均无专有或商业利益。
