Sen Hasan, Cooper Amanda, Conger Aaron, McCormick Zachary L, Przybysz Allison Glinka
Department of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, UT, United States.
Interv Pain Med. 2025 Jul 16;4(3):100614. doi: 10.1016/j.inpm.2025.100614. eCollection 2025 Sep.
Dorsal root ganglion (DRG) stimulation has emerged as an effective, targeted neuromodulation therapy for refractory pain of the lower extremities, particularly in the setting of complex regional pain syndrome. However, preliminary evidence supporting DRG for other applications, such as peripheral neuropathy or refractory nociceptive pain, is currently limited to patient populations with discrete pain sources. We report a case of chronic, multifactorial foot pain successfully treated with a right S1 DRG stimulation after failure of multiple prior interventions including physical therapy, corticosteroid injections, and surgeries.
A 74-year-old male presented with chronic refractory right foot pain, diagnosed with L5-S1 radiculopathy, peripheral neuropathy, persistent post-surgical pain following multiple procedures, including partial toe pain, which significantly impaired his mobility and quality of life. DRG stimulation was pursued after multiple prior interventions, including physical therapy, corticosteroid injections, surgeries, and a trial of peripheral nerve stimulation (PNS) that provided only temporary relief. Following a successful stimulation trial, a permanent DRG device was implanted at the S1 level, resulting in meaningful, sustained pain relief and functional improvement.
DRG stimulation represents a promising treatment for refractory lower extremity pain, especially in cases where traditional therapies have failed. This case illustrates its therapeutic potential in patients with complex refractory neuropathic pain of mixed etiologies.
背根神经节(DRG)刺激已成为治疗下肢顽固性疼痛的一种有效、靶向性神经调节疗法,尤其是在复杂性区域疼痛综合征的情况下。然而,目前支持DRG用于其他应用(如周围神经病变或顽固性伤害感受性疼痛)的初步证据仅限于具有明确疼痛源的患者群体。我们报告一例慢性、多因素足部疼痛病例,在包括物理治疗、皮质类固醇注射和手术在内的多种先前干预措施失败后,成功通过右侧S1 DRG刺激得到治疗。
一名74岁男性因慢性顽固性右足疼痛就诊,诊断为L5 - S1神经根病、周围神经病变、多次手术后持续性手术疼痛,包括部分脚趾疼痛,这严重损害了他的活动能力和生活质量。在包括物理治疗、皮质类固醇注射、手术以及一次仅提供临时缓解的周围神经刺激(PNS)试验等多种先前干预措施失败后,采用了DRG刺激。在成功进行刺激试验后,在S1水平植入了永久性DRG装置,从而实现了有意义的、持续的疼痛缓解和功能改善。
DRG刺激是治疗下肢顽固性疼痛的一种有前景的方法,尤其是在传统疗法失败的情况下。该病例说明了其在具有复杂顽固性混合病因神经病理性疼痛患者中的治疗潜力。