Ojeda V J, Shilkin K B, Walters M N
Pathology. 1985 Jul;17(3):451-4. doi: 10.3109/00313028509105499.
One hundred and twenty gall-bladders obtained at cholecystectomy for gall bladder diseases formed the basis of a prospective study of premalignant epithelial lesions. Six cases displayed abnormal mucosa (5%); 4 had atypical hyperplasia (dysplasia) and 2 gall-bladders had carcinoma-in-situ; all were associated with chronic cholecystitis and lithiasis. These changes are considered premalignant and are probably precursors of gall-bladder carcinoma. It is impossible to predict which patient with chronic gall-bladder disease is likely to harbour premalignant epithelial changes. In any event, thorough histological examination of all gall bladders removed surgically is more than justified.
对120例因胆囊疾病行胆囊切除术获得的胆囊进行了一项关于癌前上皮病变的前瞻性研究。6例显示黏膜异常（5%）；4例有非典型增生（发育异常），2例胆囊有原位癌；所有病例均与慢性胆囊炎和结石症相关。这些改变被认为是癌前病变，可能是胆囊癌的先兆。无法预测哪些患有慢性胆囊疾病的患者可能存在癌前上皮改变。无论如何，对所有手术切除的胆囊进行全面的组织学检查是完全合理的。
