Sajjad Moradi, Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; email:
J Nutr Health Aging. 2023;27(5):378-390. doi: 10.1007/s12603-023-1919-8.
We performed a current study to examine the association between dietary inflammatory index (DII) score and older age-related muscle conditions, including sarcopenia, low muscle mass, low muscle strength, frailty, and/or disability.
Systematic review and dose-response meta-analysis.
A systematic literature search was performed using Scopus, PubMed/MEDLINE, and ISI Web of Science without limitation until October 04, 2022. Relative risk (RR) and 95% confidence interval (CI) were pooled by applying a random-effects model, while validated methods examined assess quality and publication bias via Newcastle-Ottawa Scale, Egger's regression asymmetry, and Begg's rank correlation tests respectively. A dose-response meta-analysis was conducted to estimate the RRs per 1-unit increment in DII scores.
Adults (≥18 years).
The risk of older age-related muscle conditions (sarcopenia, low muscle mass, low muscle strength, frailty, and/or disability).
Data were available from 19 studies with 68079 participants. Results revealed that a higher DII score was significantly related to an increased risk of sarcopenia (RR=1.50; 95% CI: 1.26, 1.79; I2=53.3%; p<0.001; n=10; sample size =43097), low muscle strength (RR=1.47; 95% CI: 1.24, 1.74; I2=6.6%; p<0.001; n=4; sample size =9339), frailty (RR=1.61; 95% CI: 1.41, 1.84; I2=0.0%; p<0.001; study=5; participant=3882) and disability (RR=1.41; 95% CI: 1.16, 1.72; I2=58.4%; p=0.001; n=5; sample size =13760), but not low muscle mass (RR=1.24; 95% CI: 0.98, 1.56; I2=49.3%; p=0.069; n=4; sample size =11222). Additionally, results of the linear dose-response indicated that an increase of one point in the DII score was related to a 14% higher risk of sarcopenia, 6% higher risk of low muscle mass, 7% higher risk of low muscle strength, and a 7% higher risk of disability in adults. Non-linear dose-response relationships also revealed a positive linear association between the DII score and the risk of sarcopenia (Pnonlinearity = 0.097, Pdose-response<0.001), frailty (Pnonlinearity = 0.844, Pdose-response=0.010) and disability (Pnonlinearity = 0.596, Pdose-response=0.007).
Adherence to a pro-inflammatory diet was significantly associated with a higher risk of sarcopenia and other age-associated adverse effects such as low muscle strength, disability, and frailty. These results indicate a necessity to prioritize the reduction of pro-inflammatory diets to help promote overall older age-related muscle conditions.
我们进行了一项当前研究，以检验饮食炎症指数（DII）评分与年龄相关的肌肉状况之间的关联，包括肌少症、低肌肉量、低肌肉力量、虚弱和/或残疾。
系统综述和剂量反应荟萃分析。
使用 Scopus、PubMed/MEDLINE 和 ISI Web of Science 进行系统文献检索，无时间限制，截至 2022 年 10 月 04 日。应用随机效应模型汇总相对风险（RR）和 95%置信区间（CI），而验证方法分别通过纽卡斯尔-渥太华量表、Egger 回归不对称性和 Begg 秩相关检验评估质量和发表偏倚。进行剂量反应荟萃分析以估计 DII 评分每增加 1 个单位的 RR。
成年人（≥18 岁）。
年龄相关的肌肉状况（肌少症、低肌肉量、低肌肉力量、虚弱和/或残疾）的风险。
从 19 项研究中获得了数据，涉及 68079 名参与者。结果表明，较高的 DII 评分与肌少症（RR=1.50；95%CI：1.26，1.79；I2=53.3%；p<0.001；n=10；样本量=43097）、低肌肉力量（RR=1.47；95%CI：1.24，1.74；I2=6.6%；p<0.001；n=4；样本量=9339）、虚弱（RR=1.61；95%CI：1.41，1.84；I2=0.0%；p<0.001；研究=5；参与者=3882）和残疾（RR=1.41；95%CI：1.16，1.72；I2=58.4%；p=0.001；n=5；样本量=13760）的风险显著增加相关，但与低肌肉量（RR=1.24；95%CI：0.98，1.56；I2=49.3%；p=0.069；n=4；样本量=11222）无关。线性剂量反应的结果表明，DII 评分增加 1 分与肌少症风险增加 14%、低肌肉量风险增加 6%、低肌肉力量风险增加 7%和残疾风险增加 7%相关。非线性剂量反应关系也显示 DII 评分与肌少症（Pnonlinearity=0.097，Pdose-response<0.001）、虚弱（Pnonlinearity=0.844，Pdose-response=0.010）和残疾（Pnonlinearity=0.596，Pdose-response=0.007）的风险之间存在正线性关联。
遵循促炎饮食与肌少症和其他与年龄相关的不良影响（如低肌肉力量、残疾和虚弱）的风险增加显著相关。这些结果表明，有必要优先减少促炎饮食，以帮助促进整体与年龄相关的肌肉状况。
