Steman Jason A H, Buck Tristan M F, Dahmen Jari, Struijs Peter A A, Stufkens Sjoerd A S, Kerkhoffs Gino M M J
Department of Orthopedic Surgery and Sports Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Musculoskeletal Health, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Cartilage. 2025 Jul 23:19476035251357214. doi: 10.1177/19476035251357214.
IntroductionLiterature on treatment outcomes in skeletally immature patients with osteochondral lesions of the talus (OLT) is scarce. As the healing of an OLT may be fundamentally different in a skeletally immature patient, more evidence is required focusing on this specific patient group. The primary aim of this study is to assess the conversion to surgery rate after initial non-operative management in skeletally immature patients with an OLT. The secondary aims of the present study are to assess and compare the clinical outcomes and reoperations after both non-operative and surgical treatment strategies at a mid- to long-term follow-up.MethodsAll skeletally immature patients at the moment of initial treatment, treated for their primary or non-primary OLT with a minimum follow-up duration of 2 years, were included in this study. Patients with concomitant injuries were excluded. All patients started with non-operative management. In case of failure of non-operative management, patients converted to Bone Marrow Stimulation (BMS) or fixation. The primary outcome was the conversion to surgery rate after initial non-operative management. Secondary outcomes consist of reoperations at mature and immature age, pain during weight bearing, measured by the numeric rating scale (NRS), NRS of pain during rest, NRS during stair climbing, Berndt and Harty outcome question, Foot and Ankle Outcome Score (FAOS) and Short Form-36 (SF-36) and the patient satisfaction rate regarding the received treatment.ResultsA total of 52 patients, 54% female, mean age of 13.6 years, were included in this study. Median follow-up duration was 81 months (range = 24-265 months). Seventeen patients received non-operative treatment as final treatment. In total, 35 (67%) out of 52 patients required surgical treatment after initial non-operative management, of which 14 underwent BMS and 20 had fixation while skeletally immature, 1 patient that had surgical treatment as an adult was excluded for further analysis. The median NRS of pain during weight bearing was 1 (interquartile range [IQR] = 0-2), 1 (IQR = 0-3), and 0 (IQR = 0-0.5) in the (sustained) non-operative, BMS, and fixation groups, respectively ( < 0.012). No significant differences in clinical outcomes between the different treatment groups could be observed. No complications occurred after surgical treatment. Reoperation rates were 21% and 20% in the BMS and fixation groups, respectively.ConclusionsThe most important finding of this study is that 67% of the patients receiving initial non-operative management for OLTs ultimately required surgery.Level of evidenceLevel III, cross-sectional comparative study.
引言
关于骨骼未成熟的距骨骨软骨损伤(OLT)患者治疗结果的文献较少。由于骨骼未成熟患者OLT的愈合可能存在根本差异,因此需要更多针对这一特定患者群体的证据。本研究的主要目的是评估骨骼未成熟的OLT患者初始非手术治疗后的手术转化率。本研究的次要目的是在中长期随访中评估和比较非手术和手术治疗策略后的临床结果及再次手术情况。
方法
本研究纳入了所有初始治疗时骨骼未成熟、因原发性或非原发性OLT接受治疗且随访时间至少为2年的患者。伴有其他损伤的患者被排除。所有患者均首先采用非手术治疗。若非手术治疗失败,患者转而接受骨髓刺激(BMS)或固定治疗。主要结局是初始非手术治疗后的手术转化率。次要结局包括成年期和未成年期的再次手术情况、负重时的疼痛(采用数字评分量表(NRS)测量)、静息时的疼痛NRS、爬楼梯时的NRS、伯恩特和哈蒂结局问题、足踝结局评分(FAOS)和简短健康调查问卷(SF - 36)以及患者对所接受治疗的满意度。
结果
本研究共纳入52例患者,其中54%为女性,平均年龄13.6岁。中位随访时间为81个月(范围 = 24 - 265个月)。17例患者最终接受非手术治疗。52例患者中共有35例(67%)在初始非手术治疗后需要手术治疗,其中14例接受了BMS治疗,20例在骨骼未成熟时接受了固定治疗,1例成年后接受手术治疗的患者被排除在进一步分析之外。在(持续)非手术、BMS和固定治疗组中,负重时疼痛的中位NRS分别为1(四分位间距[IQR] = 0 - 2)、1(IQR = 0 - 3)和0(IQR = 0 - 0.5)(<0.012)。不同治疗组之间在临床结果方面未观察到显著差异。手术治疗后未发生并发症。BMS组和固定治疗组的再次手术率分别为21%和20%。
结论
本研究最重要的发现是,接受OLT初始非手术治疗的患者中有67%最终需要手术治疗。
证据水平
III级,横断面比较研究。