Buck Tristan M F, Dahmen Jari, Rikken Quinten G H, Hollander Julian J, Stufkens Sjoerd A S, Kerkhoffs Gino M M J
Amsterdam UMC location University of Amsterdam, Departement of Orthopedic Surgery and Sports Medicine, Amsterdam, the Netherlands.
Amsterdam Movement Sciences, Musculoskeletal Health, Amsterdam, the Netherlands.
Foot Ankle Int. 2025 Jul 10;46(9):10711007251348196. doi: 10.1177/10711007251348196.
Bone marrow stimulation (BMS) is the most frequently performed surgical procedure for osteochondral lesions of the talus (OLTs). After the surgical intervention, one of the first goals of rehabilitation is to resume weightbearing. This study aims to compare clinical and radiologic outcomes between immediate weightbearing and delayed weightbearing, which represent unrestricted weightbearing and weightbearing starting at 6 weeks postoperatively.
All patients who underwent BMS for their OLT between July 2019 and September 2022 in our clinic were screened for eligibility. Patients were retrospectively included with prospective collected data and were matched into 2 groups, the immediate weightbearing group or the delayed weightbearing group. The following variables were used for matching: age, gender, side, lesion size (volume and surface measured on CT scans), primary or nonprimary lesion, body mass index (BMI) and the numeric rating scale (NRS) of pain during walking. The primary outcome of this study is the comparison of the change in NRS of pain during walking between baseline and 12 months postoperatively, between both groups. Secondary outcomes consist of change in the NRS of pain during running, NRS pain during stairclimbing, NRS pain during rest, 36-Item Short Form Health Survey, Foot and Ankle Outcome Score, return to work, return to sport, and radiologic outcomes between both groups at 12 months.
After matching, 13 patients per group were included. Both groups showed improvement in NRS pain during walking from baseline to 12 months postoperatively. The difference in change scores between immediate and delayed weightbearing was not statistically significant ( = .57, 95% CI -3.25 to 1.86). A higher proportion of patients in the immediate weightbearing group exceeded the minimal clinically important difference threshold of 2 points compared with the delayed group (OR = 1.9, 95% CI 0.30-11.7), although this was not statistically significant. No significant between-group differences were observed in secondary clinical or radiologic outcomes, nor in return-to-work or return-to-sport rates.
This matched cohort study found no statistically significant difference in clinical or radiologic outcomes at 12 months between immediate and delayed weightbearing following arthroscopic BMS for talar osteochondral lesions. Although early weightbearing may be feasible and well tolerated, the small sample size and wide CIs limit the strength of conclusions. These findings should be considered hypothesis-generating and underscore the need for larger, prospective trials.
骨髓刺激术(BMS)是距骨骨软骨损伤(OLTs)最常施行的外科手术。手术干预后,康复的首要目标之一是恢复负重。本研究旨在比较即刻负重与延迟负重的临床和影像学结果,即刻负重代表无限制负重,延迟负重代表术后6周开始负重。
对2019年7月至2022年9月期间在我院接受BMS治疗OLT的所有患者进行资格筛查。回顾性纳入患者并前瞻性收集数据,将患者匹配分为2组,即即刻负重组或延迟负重组。用于匹配的变量如下:年龄、性别、患侧、病变大小(CT扫描测量的体积和表面积)、原发性或非原发性病变、体重指数(BMI)以及行走时疼痛的数字评定量表(NRS)。本研究的主要结局是比较两组患者术后12个月与基线相比行走时疼痛NRS的变化。次要结局包括跑步时疼痛NRS的变化、爬楼梯时疼痛NRS、休息时疼痛NRS、36项简短健康调查问卷、足踝结局评分、恢复工作情况、恢复运动情况以及两组术后12个月的影像学结果。
匹配后,每组纳入13例患者。两组患者术后12个月行走时疼痛NRS均较基线有所改善。即刻负重组与延迟负重组变化评分的差异无统计学意义(P = 0.57,95%CI -3.25至1.86)。与延迟负重组相比,即刻负重组中超过最小临床重要差异阈值2分的患者比例更高(OR = 1.9, 95%CI 0.30 - 11.7),尽管这无统计学意义。在次要临床或影像学结局、恢复工作或恢复运动率方面,未观察到显著的组间差异。
这项匹配队列研究发现,关节镜下BMS治疗距骨骨软骨损伤后,即刻负重与延迟负重在12个月时的临床或影像学结局无统计学显著差异。尽管早期负重可能可行且耐受性良好,但样本量小和置信区间宽限制了结论的力度。这些发现应被视为提出假设,并强调需要进行更大规模的前瞻性试验。