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鼻科手术在阻塞性睡眠呼吸暂停(OSA)手术中起关键作用,但并非首要作用——一项基于25年证据的系统评价

Nasal surgery is pivotal, not primary, in OSA surgery - a 25-year evidence based systematic review.

作者信息

Pang Kenny P, Cheong Ryan C T, Lim Joon Wei, Vicini Claudio, Pang Scott B, Siow Jin Keat, Pang Charlotte E, Rotenberg Brian

机构信息

Asia Sleep Centre Consultant Otolaryngology, 290 Orchard Road, Unit 18-04,, Paragon, 238859, Singapore.

Royal National ENT Hospital Consultant, Otolaryngology, London, UK.

出版信息

Eur Arch Otorhinolaryngol. 2025 Jul 23. doi: 10.1007/s00405-025-09553-z.

Abstract

OBJECTIVE

To investigate the contribution of nasal surgery to multilevel OSA surgical success outcome.

METHODS

Systematic review of MEDLINE, Google Scholar, Cochrane Library and Evidence Based Medicine Reviews to identify publications relevant to OSA, nasal resistance, pharyngeal volume/space, nasal surgery, multilevel surgery and its outcomes. All relevant studies published between January 2000 to December 2024 were included.

RESULTS

Twelve studies were included in this systematic review with 11 articles illustrating that nasal surgery was pivotal, and improved outcomes in multilevel OSA surgery, whilst nasal surgery alone for OSA did not significantly affect polysomnographic results. Five articles utilizing CBCT, 3D measurements of nasal and pharyngeal airway area/volume, computational fluid dynamics and nasal resistance demonstrated that reducing nasal resistance with nasal surgery increased the pharyngeal airway space and volume; whilst 6 articles established through clinical case studies that multilevel OSA surgery combined with nasal surgery yielded better AHI, LSAT and ESS outcomes than multilevel surgery without nasal surgery. The landmark article that reviewed 24 years of nasal surgery alone for OSA treatment, showed poor outcomes and minimal AHI change with nasal surgery alone.

CONCLUSION

As the upper airway is a continuous air conduit, reducing nasal resistance would reduce pharyngeal pressures leading to improvement of outcome parameters. Hence, including nose surgery in multilevel surgery improves surgical success.

摘要

目的

探讨鼻部手术对多平面阻塞性睡眠呼吸暂停(OSA)手术成功结局的贡献。

方法

对MEDLINE、谷歌学术、考克兰图书馆和循证医学综述进行系统评价,以识别与OSA、鼻阻力、咽腔容积/空间、鼻部手术、多平面手术及其结局相关的出版物。纳入2000年1月至2024年12月期间发表的所有相关研究。

结果

本系统评价纳入了12项研究,其中11篇文章表明鼻部手术至关重要,并改善了多平面OSA手术的结局,而单独进行鼻部手术治疗OSA对多导睡眠图结果没有显著影响。5篇文章利用锥形束计算机断层扫描(CBCT)、鼻腔和咽气道面积/容积的三维测量、计算流体动力学和鼻阻力,证明鼻部手术降低鼻阻力可增加咽气道空间和容积;而6篇通过临床病例研究表明,多平面OSA手术联合鼻部手术比不进行鼻部手术的多平面手术产生更好的呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSAT)和爱泼沃斯思睡量表(ESS)结局。一篇具有里程碑意义的文章回顾了24年单独进行鼻部手术治疗OSA的情况,结果显示单独进行鼻部手术效果不佳,AHI变化极小。

结论

由于上气道是一个连续的空气管道,降低鼻阻力会降低咽腔压力,从而改善结局参数。因此,在多平面手术中纳入鼻部手术可提高手术成功率。

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