贯叶连翘乙醇提取物对肉鸡生长性能、血清代谢物、脂肪沉积、免疫力和脂质过氧化的影响

The Influence of Ethanolic Extract of Hypericum Perforatum (St. John's wort) on Growth Performance, Serum Metabolites, Fat Deposition, Immunity, and Lipid Peroxidation in Broiler Chickens.

作者信息

Behroozilak Mohammad Ali, Moftakharzadeh Seyed Adel, Behroozlak Morteza, Vahedi Vahid, Bakhshalizadeh Somayeh

机构信息

Animal Science Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

Department of Animal Science, Payame Noor University, Tehran, Iran.

出版信息

Vet Med Sci. 2025 Sep;11(5):e70507. doi: 10.1002/vms3.70507.

DOI:10.1002/vms3.70507

PMID:40699554

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12285605/

Abstract

BACKGROUND

Having bioactive components such as hypericin, hyperforin and quercetin has enabled Hypericum perforatum (HP) to show antioxidant, antiviral and hypocholesterolemic effects in different animal species.

OBJECTIVES

This study aimed to investigate the effects of different levels of Hypericum perforatum extract (HPE) additions on performance, immune response, serum metabolites, and lipid peroxidation in broiler chickens.

METHODS

A total of 250 one-day-old broiler chicks were randomly allocated to five treatments with five replicates and ten chicks each. Experimental rations consisted of a basal diet with no supplement (control group) and a basal diet with 0.1%, 0.5%, 1%, and 1.5% HPE.

RESULTS

Results showed that the addition 1.5% HPE in the broiler diet increased high-density lipoproteins (HDL) compared to the control diet. While the total cholesterol (TC) was significantly reduced by HPE supplementation, only feeding 1% and 1.5% HPE significantly lowered the low-density lipoproteins (LDL). HPE addition to the diet significantly reduced abdominal and breast fat at 0.5%, 1%, and 1.5% levels. However, thigh fat was significantly decreased by dietary all HPE levels supplementation. Moreover, in the group fed with 1.5% HPE, the immunoglobulin G (IgG) and thymus weight significantly increased compared to the control group. Compared with the control group, HPE-fed groups showed significantly lower malondialdehyde (MDA) concentrations in breast muscle. The total antioxidant capacity (T-AOC) was improved significantly by HPE supplementation.

CONCLUSIONS

In general, while there was no significant difference among treatments in the case of growth performance parameters, dietary supplementation of HPE at 1.5% was the most effective dose to improve serum biochemical metabolites, fat metabolism, immune response, and oxidative stability in broiler chicks.

摘要

背景

贯叶连翘（HP）含有金丝桃素、金丝桃苷和槲皮素等生物活性成分，使其在不同动物物种中表现出抗氧化、抗病毒和降胆固醇作用。

目的

本研究旨在探讨添加不同水平贯叶连翘提取物（HPE）对肉鸡生产性能、免疫反应、血清代谢产物和脂质过氧化的影响。

方法

将250只1日龄肉鸡随机分为5组，每组5个重复，每个重复10只鸡。实验日粮包括不添加任何物质的基础日粮（对照组）以及添加0.1%、0.5%、1%和1.5% HPE的基础日粮。

结果

结果表明，与对照日粮相比，在肉鸡日粮中添加1.5% HPE可提高高密度脂蛋白（HDL）水平。虽然补充HPE可显著降低总胆固醇（TC），但仅饲喂1%和1.5% HPE可显著降低低密度脂蛋白（LDL）。日粮中添加HPE在0.5%、1%和1.5%水平时可显著降低腹部和胸部脂肪。然而，日粮中添加所有水平的HPE均可显著降低大腿脂肪。此外，与对照组相比，饲喂1.5% HPE组的免疫球蛋白G（IgG）和胸腺重量显著增加。与对照组相比，饲喂HPE组的胸肌中丙二醛（MDA）浓度显著降低。补充HPE可显著提高总抗氧化能力（T-AOC）。