Cervini M A, Rossi A C, Perseo G, de Castiglione R
Peptides. 1985 May-Jun;6(3):433-7. doi: 10.1016/0196-9781(85)90109-3.
A series of hepta-, hexa-, penta- and tetrapeptide analogues of dermorphin have been evaluated in the rat for antinociceptive activity after subcutaneous (SC) administration at the screening dose of 4 mg/kg. Effective doses (ED50) were calculated for the most active compounds. Presence of spontaneous movements, defecation, micturition and corneal reflex were also recorded. Syntheses and analytical data of new derivatives are briefly reported.
已对一系列的皮肤吗啡七肽、六肽、五肽和四肽类似物在大鼠皮下注射4mg/kg的筛选剂量后进行了抗伤害感受活性评估。计算了最具活性化合物的有效剂量（ED50）。还记录了自发运动、排便、排尿和角膜反射的情况。简要报告了新衍生物的合成及分析数据。
