Rossi A, di Salle E, Briatico G, Arcari G, de Castiglione R, Perseo G
Peptides. 1983 Jul-Aug;4(4):577-80. doi: 10.1016/0196-9781(83)90064-5.
A series of analogues and shorter homologues of dermorphin (DM), a frog skin heptapeptide with potent morphine-like activity, have been assayed in the rat after subcutaneous (SC) administration at the screening dose of 4 mg/kg. The effects taken into account are: analgesia (tail-pinch test), stimulation of prolactin (PRL) secretion, and inhibition of gastro-intestinal (GI) motility (charcoal meal transit). Effective doses were calculated for the most active compounds. The potency of DM (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) in the different tests was: tail-pinch: ED50 = 0.83 mg/kg; PRL release: ED100 = 0.3 mg/kg; inhibition of GI motility: ED30 = 1.8 mg/kg.
肤吗啡（DM）是一种具有强吗啡样活性的蛙皮七肽，已对其一系列类似物和较短的同系物以4mg/kg的筛选剂量进行皮下注射后在大鼠体内进行了测定。所考虑的效应包括：镇痛（夹尾试验）、催乳素（PRL）分泌刺激以及胃肠（GI）蠕动抑制（炭末推进试验）。计算了最具活性化合物的有效剂量。DM（H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2）在不同试验中的效力为：夹尾试验：ED50 = 0.83mg/kg；PRL释放：ED100 = 0.3mg/kg；胃肠蠕动抑制：ED30 = 1.8mg/kg。
