da Silva Castanheira Jason, Poli Jonathan, Hansen Justine Y, Misic Bratislav, Baillet Sylvain
Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
CentraleSupélec, Université Paris-Saclay, Paris, France.
Sci Adv. 2025 Jul 25;11(30):eads7544. doi: 10.1126/sciadv.ads7544. Epub 2025 Jul 23.
Neurophysiological brain activity shapes cognitive functions and individual traits. Here, we investigated the extent to which individual neurophysiological properties are genetically determined and how these adult traits align with cortical gene expression patterns across development. Using task-free magnetoencephalography in monozygotic and dizygotic twins, as well as unrelated individuals, we found that neurophysiological traits were significantly more similar between monozygotic twins, indicating a genetic influence, although individual-specific variability remained predominant. These heritable brain dynamics were mainly associated with genes involved in neurotransmission, expressed along a topographical gradient that mirrors psychological functions, including attention, planning, and emotional processes. Furthermore, the cortical expression patterns of genes associated with individual differentiation aligned most strongly with gene expression profiles observed during adulthood in previously published longitudinal datasets. These findings underscore a persistent genetic influence on neurophysiological activity, supporting individual cognitive and behavioral variability.
神经生理大脑活动塑造认知功能和个体特征。在此，我们研究了个体神经生理特性在多大程度上由基因决定，以及这些成人特征在整个发育过程中如何与皮质基因表达模式相匹配。通过对同卵双胞胎、异卵双胞胎以及无血缘关系个体进行无任务脑磁图检查，我们发现同卵双胞胎之间的神经生理特征显著更相似，这表明存在遗传影响，尽管个体特异性变异性仍然占主导。这些可遗传的脑动力学主要与参与神经传递的基因相关，这些基因沿反映心理功能（包括注意力、计划和情感过程）的地形梯度表达。此外，与个体分化相关的基因的皮质表达模式与先前发表的纵向数据集中成年期观察到的基因表达谱最为紧密匹配。这些发现强调了对神经生理活动的持续遗传影响，支持个体认知和行为变异性。
