眼部结节病继发小儿视乳头周围脉络膜新生血管形成：1例长期随访病例
Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case.
作者信息
Zong Yuan, Wang Keyan, Zhang Ting, Xu Gezhi
机构信息
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, 200031, China.
出版信息
BMC Ophthalmol. 2025 Jul 23;25(1):422. doi: 10.1186/s12886-025-04266-7.
BACKGROUND
To describe a 14-year-old male with probable ocular sarcoidosis and bilateral peripapillary choroidal neovascularization (PCNV).
CASE PRESENTATION
We report a case of a 14-year-old boy with a 2-month history of floaters and gradual vision loss in both eyes. Examination revealed bilateral granulomatous uveitis with peripapillary subretinal lesions. The serum angiotensin-converting enzyme was elevated. Positron emission tomography demonstrated increased metabolic activity in the nasopharynx and small intestine, consistent with diagnosis of sarcoidosis. Despite resolution of vitreous cells and retinal vasculitis, the PCNV progressed slowly in the left eye, which was controlled with combined treatment of immunomodulatory regiment and multiple intravitreal anti-vascular endothelial growth factor injections over a prolonged period.
CONCLUSIONS
This case highlights the need for a multidisciplinary approach and long-term follow-up in pediatric ocular sarcoidosis with PCNV.
背景
描述一名患有可能的眼部结节病和双侧视乳头周围脉络膜新生血管（PCNV）的14岁男性。
病例报告
我们报告一例14岁男孩，有2个月的双眼飞蚊症和逐渐视力丧失病史。检查发现双侧肉芽肿性葡萄膜炎伴视乳头周围视网膜下病变。血清血管紧张素转换酶升高。正电子发射断层扫描显示鼻咽部和小肠代谢活性增加，符合结节病诊断。尽管玻璃体细胞和视网膜血管炎消退，但左眼PCNV进展缓慢，通过长期联合免疫调节方案和多次玻璃体内抗血管内皮生长因子注射进行控制。
结论
该病例强调了对患有PCNV的儿童眼部结节病采取多学科方法和长期随访的必要性。
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