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从缩水甘油醛和未保护的核苷酸碱基直接一锅法合成2-碘-2-脱氧核苷及其对日本脑炎病毒的生物学评价

One pot access to 2-iodo-2-deoxy nucleosides directly from glycals and unprotected nucleobases and their biological evaluation on the Japanese Encephalitis Virus.

作者信息

Sakander Norein, Archana Km, Ahmed Ajaz, Mishra Shriyanshi, Tripathi Raj Kamal, Mukherjee Debaraj

机构信息

Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine Jammu-180001 India.

Academy of Scientific and Innovative Research (AcSIR) Ghaziabad-201002 India.

出版信息

RSC Adv. 2025 Jul 23;15(32):26490-26496. doi: 10.1039/d5ra02382c. eCollection 2025 Jul 21.

DOI:10.1039/d5ra02382c
PMID:40703068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12285759/
Abstract

An expedient one-pot stereo- and regioselective synthesis of 2-iodo-nucleosides from protected glycals and nucleobases using easily available iodine and hexamethyldisilane as halogenating, and silylating agents respectively has been developed. Most of the products synthesized characterized as diastereomerically pure β-1,2-trans-diequitorial nucleosides hitherto not reported. The studies unveil the cogent antiviral activity of these newly synthesized nucleoside derivatives against the Japanese Encephalitis Virus (flavivirus) in the Vero cell line.

摘要

已开发出一种便捷的一锅法立体和区域选择性合成方法，该方法使用易于获得的碘和六甲基二硅烷分别作为卤化剂和硅烷化剂，从受保护的缩水甘油醛和核碱基合成2-碘代核苷。所合成的大多数产物被表征为非对映体纯的β-1,2-反式-双赤道核苷，这是迄今尚未报道过的。这些研究揭示了这些新合成的核苷衍生物在Vero细胞系中对日本脑炎病毒（黄病毒）具有较强的抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/80e196040378/d5ra02382c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/d4539a026af3/d5ra02382c-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/e99b2568f2fd/d5ra02382c-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/601b52ebabbc/d5ra02382c-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/033be2ec7e14/d5ra02382c-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/0a5bccc96aa4/d5ra02382c-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/a0342772f1d5/d5ra02382c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/80e196040378/d5ra02382c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/d4539a026af3/d5ra02382c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/10ca77429d68/d5ra02382c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/e99b2568f2fd/d5ra02382c-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/601b52ebabbc/d5ra02382c-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/033be2ec7e14/d5ra02382c-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/0a5bccc96aa4/d5ra02382c-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/a0342772f1d5/d5ra02382c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b85/12285759/80e196040378/d5ra02382c-f3.jpg

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本文引用的文献

1
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2
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Biochem Pharmacol. 2023 Sep;215:115741. doi: 10.1016/j.bcp.2023.115741. Epub 2023 Aug 9.
3
Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses.具有抗登革热和日本脑炎病毒选择性抗病毒活性的核苷类似物。
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.00397-19. Print 2019 Jul.
4
Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates.树枝状聚合物缀合物的酶解呈负树枝状效应。
Chem Commun (Camb). 2018 Jun 8;54(47):5956-5959. doi: 10.1039/c8cc01221k.
5
The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.核苷类似物抗病毒药物的演进：化学家与非化学家的综述。第 1 部分：核苷骨架的早期结构修饰。
Antiviral Res. 2018 Jun;154:66-86. doi: 10.1016/j.antiviral.2018.04.004. Epub 2018 Apr 10.
6
Hypervalent iodine mediated synthesis of C-2 deoxy glycosides and amino acid glycoconjugates.高价碘介导的 C-2 去氧糖苷和氨基酸糖缀合物的合成。
J Org Chem. 2014 May 16;79(10):4470-6. doi: 10.1021/jo500465m. Epub 2014 May 5.
7
Current approaches in antiviral drug discovery against the Flaviviridae family.针对黄病毒科的抗病毒药物研发的当前方法。
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8
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Nat Rev Drug Discov. 2013 Jun;12(6):447-64. doi: 10.1038/nrd4010.
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J Control Release. 2013 Apr 28;167(2):200-9. doi: 10.1016/j.jconrel.2013.01.020. Epub 2013 Feb 4.
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