乙酰水杨酸、水杨酰胺和非那西丁在不同pH值下的可用性研究。
Availability studies on acetylsalicylic acid, salicylamide and phenacetin at different pH values.
作者信息
el-Sourady H A, Habib F S, Mohamed S I
出版信息
Pharmazie. 1985 Sep;40(9):639-41.
The optimum partitioning rate of acetylsalicylic acid has been attained at pH = 4 and minimum partitioning rate was found to be at pH = 8. The maximum partitioning rate of salicylamide was observed at pH = 5 and the smallest one was found at pH = 6 or 8. At pH = 3 a maximum amount of phenacetin was found in the aqueous phase, while at pH = 6 a maximum amount was found in the octanolic layer. The maximum partitioning rate was found at pH = 6 and lowest one was observed at pH = 3. The gastrointestinal absorption of acetylsalicylic acid, salicylamide and phenacetin was significantly increased, as reflected by the urinary excretion data in presence of solid buffer components at pH values of 4,5 and 6 respectively.
乙酰水杨酸的最佳分配率在pH = 4时达到，而最低分配率在pH = 8时被发现。水杨酰胺的最大分配率在pH = 5时观察到，最小分配率在pH = 6或8时被发现。在pH = 3时，水相中发现最大量的非那西汀，而在pH = 6时，辛醇层中发现最大量。最大分配率在pH = 6时被发现，最低分配率在pH = 3时被观察到。乙酰水杨酸、水杨酰胺和非那西汀的胃肠道吸收显著增加，分别在pH值为4、5和6的固体缓冲成分存在下，通过尿液排泄数据反映出来。
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