Banks William A
Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Neurobiol Sleep Circadian Rhythms. 2025 Feb 13;18(Suppl):100114. doi: 10.1016/j.nbscr.2025.100114. eCollection 2025 May.
In this article for Dr Krueger's Festschrift, I trace how his early career influenced many aspects in the fields of sleep, neuroimmunology, and the microbiome. Mostly, however, I trace how his career and interests intertwined with those of Abba J. Kastin and mine and how he exerted a profound influence on the direction of our studies. Dr. Krueger, while developing his career as a sleep researcher, encountered resistance to his work that required two major paradigm shifts: 1) that bacterial products could affect sleep and 2) that small peptides can cross the blood-brain barrier (BBB) in sufficient amounts to affect brain functioning. Dr Kastin had also shown that small peptides administered peripherally could affect brain function and postulated that this was because they could cross the BBB. Our efforts to determine whether peptides could or could not cross the BBB were bolstered by Dr Krueger's exemplary struggles.
在这篇为祝贺克鲁格博士而作的文章中，我追溯了他早期的职业生涯如何影响睡眠、神经免疫学和微生物组领域的诸多方面。然而，我主要追溯了他的职业生涯和兴趣是如何与阿巴·J·卡斯汀以及我的交织在一起的，以及他如何对我们的研究方向产生了深远影响。克鲁格博士在发展其作为睡眠研究员的职业生涯时，其工作遭遇了阻力，这需要两次重大的范式转变：一是细菌产物可影响睡眠；二是小肽能够以足够的量穿过血脑屏障（BBB）从而影响大脑功能。卡斯汀博士也曾表明，外周给予的小肽可影响大脑功能，并推测这是因为它们能够穿过血脑屏障。克鲁格博士堪称典范的奋斗历程，推动了我们确定肽能否穿过血脑屏障的研究工作。
