Opp Mark R, Imeri Luca
Department of Integrative Physiology, University of Colorado Boulder, United States.
Department of Health Sciences, University of Milan, Italy.
Neurobiol Sleep Circadian Rhythms. 2025 Apr 15;18(Suppl):100118. doi: 10.1016/j.nbscr.2025.100118. eCollection 2025 May.
Chronic insufficient sleep kills! Although this statement has high 'face validity', it is only recently that empirical evidence existed to support it. There are now sufficient data for numerous meta-analyses and systematic reviews to demonstrate that chronic insufficient sleep is associated with many inflammatory pathologies that are a public health burden. As a result, it is now well accepted that sleep is important for physical and mental health. This awareness derives from research that began in the late 19th and early 20th centuries and continues to the present day. In this narrative review we trace this rich history within the context of the research contributions of Professor James Krueger and his colleagues. The historic and current research by Professor Krueger and colleagues is fundamental to the many ongoing pre-clinical and clinical research programs focused on all aspects of sleep and immune health.
长期睡眠不足会致命！尽管这一说法表面上很有说服力，但直到最近才有实证证据支持它。现在有足够的数据进行大量的荟萃分析和系统评价，以证明长期睡眠不足与许多作为公共卫生负担的炎症性疾病有关。因此，现在人们普遍认为睡眠对身心健康很重要。这种认识源于19世纪末20世纪初开始并持续至今的研究。在这篇叙述性综述中，我们在詹姆斯·克鲁格教授及其同事的研究贡献背景下追溯这段丰富的历史。克鲁格教授及其同事的历史和当前研究对于许多正在进行的专注于睡眠和免疫健康各个方面的临床前和临床研究项目至关重要。
