Mostafa Mohamed A, Kingsley Jeff A, Soliman Elsayed Z, Bhave Prashant D
Department of Cardiovascular medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Front Cardiovasc Med. 2025 Jul 9;12:1476935. doi: 10.3389/fcvm.2025.1476935. eCollection 2025.
Literature on the association between high body mass index (BMI) and cardiac conduction defects (CCD) is scarce.
The cross-sectional association between obesity and CCD was examined in 455,790 participants (56.1 years; 55.9% females) from the United Kingdom (UK) Biobank. CCD was defined by ICD codes as the presence of either atrioventricular block (AVB) or intraventricular block (IVB). Multivariable logistic regression models were used to assess the association between different levels of BMI and CCD.
About 2.7% ( = 12,169) of the participants exhibited CCD. Each 1-SD increase in BMI (4.68 kg/m) was associated with increased odds of CCD (OR (95% CI): 1.03 (1.01, 1.06). In subgroup analysis, this association was stronger in older participants (>65 vs. <65 years), men than women, and participants with diabetes (interaction -value < 0.05 for all). In a stratified analysis by CCD subtypes, each 1-SD of BMI was associated with increased odds of AVB, but not IVB [OR (95% CI): 1.04 (1.01, 1.07), 0.97 (0.89, 1.05), respectively]. Compared to normal BMI (25-29.9 Kg/m), participants with marked obesity, defined as BMI >40 Kg/m, had 20% increased odds of CCD (OR (95% CI): 1.20 (1.04, 1.39). No significant association was observed with BMI between 30 and 39.9 Kg/m.
Higher BMI levels are associated with an increased risk of CCD, which is probably triggered by AVB, and the association is stronger in men, the elderly, and those with diabetes; further research is needed to examine whether weight management in obesity will be accompanied by a reduction in the risk of CCD.
关于高体重指数（BMI）与心脏传导缺陷（CCD）之间关联的文献较少。
在来自英国生物银行的455,790名参与者（年龄56.1岁；女性占55.9%）中研究肥胖与CCD之间的横断面关联。CCD通过国际疾病分类代码定义为存在房室传导阻滞（AVB）或室内传导阻滞（IVB）。使用多变量逻辑回归模型评估不同BMI水平与CCD之间的关联。
约2.7%（n = 12,169）的参与者表现出CCD。BMI每增加1个标准差（4.68 kg/m²）与CCD发生几率增加相关（比值比（95%置信区间）：1.03（1.01，1.06））。在亚组分析中，这种关联在老年参与者（>65岁与<65岁）、男性中比女性更强，以及在糖尿病患者中更强（所有交互P值<0.05）。在按CCD亚型进行的分层分析中，BMI每增加1个标准差与AVB发生几率增加相关，但与IVB无关[比值比（95%置信区间）分别为1.04（1.01，1.07），0.97（0.89，1.05）]。与正常BMI（25 - 29.9 Kg/m²）相比，定义为BMI>40 Kg/m²的显著肥胖参与者患CCD的几率增加20%（比值比（95%置信区间）：1.20（1.04，1.39））。在30至39.9 Kg/m²的BMI之间未观察到显著关联。
较高的BMI水平与CCD风险增加相关，这可能由AVB引发，并且这种关联在男性、老年人和糖尿病患者中更强；需要进一步研究以检查肥胖症患者的体重管理是否会伴随着CCD风险的降低。
