Madi Marwa, Al-Naief Nasser S, Alagl Adel S
Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Front Oral Health. 2025 Jul 9;6:1630504. doi: 10.3389/froh.2025.1630504. eCollection 2025.
To evaluate dimensional changes and new bone formation using two deproteinized bovine bone minerals, NuOss and Bio-Oss, in socket preservation.
Eighteen patients (6 males, 12 females; aged 23-45 years) requiring posterior tooth extraction were enrolled. Eighteen extraction sockets were augmented with either NuOss or Bio-Oss and covered with a collagen membrane. After six months, Cone Beam Cephalometry (CBCT) assessed dimensional changes in buccolingual width and buccal bone thickness. Bone core biopsies were obtained during implant placement and decalcified for histomorphologic examination. Statistical analysis compared dimensional changes and histomorphometric parameters between groups.
All experimental sites healed uneventfully, with complete soft tissue healing within four weeks and successful implant placement. CBCT scans showed comparable, non-significant dimensional reductions. Histomorphologic examination revealed lamellar cortical bone and osteoid trabeculae with partial to optimal integration. NuOss demonstrated significantly higher new bone formation (52.5 ± 2.5%) compared to Bio-Oss (37.5 ± 2.5%; = 0.0021), with lower residual graft material (27.5 ± 2.5% vs. 42.5 ± 2.5%; = 0.0018). Bio-Oss grafted cases exhibited more pronounced inflammatory cell infiltration. Soft tissue proportions were similar between groups (NuOss: 22.5 ± 2.5%, Bio-Oss: 17.5 ± 2.5%; = 0.0892).
Both NuOss and Bio-Oss showed positive bone regeneration effects. However, NuOss demonstrated more favorable biocompatibility, with less inflammation and improved bone integration than Bio-Oss.
使用两种脱蛋白牛骨矿物质NuOss和Bio-Oss评估牙槽窝保存中的尺寸变化和新骨形成情况。
纳入18例需要拔除后牙的患者（6例男性，12例女性；年龄23 - 45岁）。18个拔牙窝分别用NuOss或Bio-Oss进行植骨，并覆盖胶原膜。6个月后，采用锥形束计算机断层扫描（CBCT）评估颊舌径宽度和颊侧骨厚度的尺寸变化。在种植体植入时获取骨芯活检标本并进行脱钙处理，以进行组织形态学检查。统计分析比较两组之间的尺寸变化和组织形态计量学参数。
所有试验部位均顺利愈合，四周内软组织完全愈合，种植体植入成功。CBCT扫描显示尺寸减小程度相当，无显著差异。组织形态学检查显示为板层状皮质骨和类骨质小梁，融合程度为部分至最佳。与Bio-Oss（37.5±2.5%；P = 0.0021）相比，NuOss的新骨形成明显更高（52.5±2.5%），残余移植材料更少（27.5±2.5% 对 42.5±2.5%；P = 0.0018）。Bio-Oss植骨病例的炎症细胞浸润更明显。两组之间的软组织比例相似（NuOss：22.5±2.5%，Bio-Oss：17.5±2.5%；P = 0.0892）。
NuOss和Bio-Oss均显示出积极的骨再生效果。然而，与Bio-Oss相比，NuOss表现出更良好的生物相容性，炎症更少，骨整合更好。
