Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032, Zurich, Switzerland.
Laboratory of Experimental Surgery and Surgical Research N. S. Christeas, Medical School, University of Athens, Athens, Greece.
Clin Oral Investig. 2018 Jul;22(6):2187-2197. doi: 10.1007/s00784-017-2309-6. Epub 2017 Dec 26.
To test whether or not one out of two alloplastic materials used for ridge preservation (RP) is superior to the other in terms of volumetric and linear ridge changes over time.
In 16 adult beagle dogs, the distal roots of P3 and P4 were extracted and 50% of the buccal bone plate removed. Ridge preservation was performed randomly using two different alloplastic bone grafting substitutes (poly lactic-co-glycolic acid (PLGA) coated biphasic calcium phosphate particles consisting of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (ß-TCP=test 1), (a biphasic calcium phosphate consisting 60% HA and 40% ß-TCP=test 2) and a resorbable collagen membrane or a control group (sham). Sacrifice was performed at three time-points (4, 8, 16 weeks later). Impressions were taken before extraction, after RP, and at sacrifice, allowing for assessment of volumetric changes. A multi-way ANOVA was computed, and partial Type-II F tests were performed.
Both ridge preservation procedures minimized the volume loss compared to spontaneous healing. The median buccal volume changes between pre-extraction and sacrifice were - 1.76 mm (Q1 = - 2.56; Q3 = - 1.42) for test 1, - 1.62 mm (Q1 = - 2.06; Q3 = - 1.38) for test 2, and - 2.42 mm (Q1 = - 2.63; Q3 = - 2.03) for control. The mean ridge width measurements did not show statistically significant differences between test 1 (- 2.51 mm; Q1 = - 3.25; Q3 = - 1.70) and test 2 (- 2.04 mm; Q1 = - 3.82; Q3 = - 1.81) (p = 0.813), but between test and control (- 3.85 mm; Q1 = - 5.02; Q3 = - 3.27) (p = 0.003).
Both RP techniques were successful in maintaining the buccal contour from pre-extraction to sacrifice to a similar extent and more favorable compared to spontaneous healing.
Alloplastic materials can successfully be used for RP procedures.
测试在用于牙槽嵴保存（RP）的两种同种异体材料中，有 1 种材料在体积和线性嵴向变化方面是否优于另 1 种。
在 16 只成年比格犬中，P3 和 P4 的根尖被拔出，50%的颊骨板被去除。随机使用两种不同的同种异体骨移植替代物（聚乳酸-共-羟基乙酸（PLGA）涂覆的双相磷酸钙颗粒，由 60%羟基磷灰石（HA）和 40%β-磷酸三钙（β-TCP=试验 1），（由 60%HA 和 40%β-TCP 组成的双相磷酸钙=试验 2）和可吸收胶原膜或对照组（假手术）进行牙槽嵴保存。在三个时间点（4、8、16 周后）进行处死。在拔牙前、RP 后和处死时采集印模，以评估体积变化。进行了多因素方差分析，并进行了部分 Type-II F 检验。
两种 RP 程序均最大限度地减少了与自发愈合相比的体积损失。试验 1 的颊侧体积变化中位数为从拔牙前到处死时的-1.76mm（Q1=-2.56；Q3=-1.42），试验 2 为-1.62mm（Q1=-2.06；Q3=-1.38），对照组为-2.42mm（Q1=-2.63；Q3=-2.03）。试验 1 的平均嵴宽度测量值（-2.51mm；Q1=-3.25；Q3=-1.70）和试验 2（-2.04mm；Q1=-3.82；Q3=-1.81）之间没有统计学意义（p=0.813），但与对照组（-3.85mm；Q1=-5.02；Q3=-3.27）之间存在统计学意义（p=0.003）。
两种 RP 技术在维持颊侧轮廓方面都取得了成功，从拔牙前到处死，其效果与自发愈合相似，甚至更有利。
同种异体材料可成功用于 RP 程序。
