Wilson L M, Sinha H L
Physiol Behav. 1985 Oct;35(4):545-8. doi: 10.1016/0031-9384(85)90138-6.
Chronically lower colonic temperatures (TcS) of genetically-obese (ob/ob) mice at ambient temperatures below thermoneutrality have led to speculation that these mutants regulate a lowered thermal setpoint relative to lean mice. Previous experiments, however, have not provided an opportunity for obese mice to exhibit compensatory thermoregulatory behaviors which might reinstate normal body temperature. In the present experiment, adult obese and lean (+/?) mice were tested at room temperature (25 degrees C) on a copper bar, thermal gradient to determine what temperatures they would select and what effect their selection would have on their TcS. The data revealed that ob/obs were more frequently observed within 25-35 degrees C locales than were lean controls, which spent more time in the below-25 degrees C zone (p less than 0.005). Ob/obs also raised their TcS to pretest values of leans' TcS, although ob/obs' TcS remained significantly lower than those of leans at the conclusion of testing. These data suggest that the hypothermia exhibited by the ob/ob may reflect both the absence of the opportunity to behaviorally thermoregulate and a genetic defect in thermogenesis.
在低于热中性的环境温度下，基因肥胖（ob/ob）小鼠的结肠温度长期较低（TcS），这引发了一种推测，即相对于瘦小鼠，这些突变体调节的热设定点较低。然而，先前的实验没有为肥胖小鼠提供表现出补偿性体温调节行为的机会，而这种行为可能会恢复正常体温。在本实验中，成年肥胖小鼠和瘦（+/？）小鼠在室温（25摄氏度）下在铜棒热梯度上进行测试，以确定它们会选择什么温度以及它们的选择对其TcS有什么影响。数据显示，与瘦对照相比，ob/ob小鼠在25 - 35摄氏度区域内出现的频率更高，瘦对照在低于25摄氏度的区域花费更多时间（p < 0.005）。ob/ob小鼠还将其TcS提高到瘦小鼠测试前的TcS值，尽管在测试结束时，ob/ob小鼠的TcS仍显著低于瘦小鼠。这些数据表明，ob/ob小鼠表现出的体温过低可能既反映了缺乏行为性体温调节的机会，也反映了产热方面的遗传缺陷。
