[突触前肾上腺素能β受体阻断能否解释普萘洛尔的降压作用？]
[Can blockade of presynaptic adrenergic beta receptors explain the antihypertensive effects of propranolol?].
作者信息
Montastruc J L, Montastruc P
出版信息
C R Seances Acad Sci D. 1979 Jul 2;289(1-2):37-40.
PMID:40705
Abstract
Pretreatment with 6-hydroxydopamine abolished the antihypertensive effects of intravenously and intracisternally administered dl-propranolol in dogs with acute neurogenic hypertension. These results show that the anti-hypertensive action of this drug is dependant on the integrity of central catecholaminergic neurones and suggest an action on presynaptic bêta-adrenoceptors.
摘要
用6-羟基多巴胺预处理可消除急性神经源性高血压犬静脉内和脑池内给予dl-普萘洛尔的降压作用。这些结果表明，该药的降压作用依赖于中枢儿茶酚胺能神经元的完整性，并提示其作用于突触前β-肾上腺素能受体。
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