Zhao Yuchen, Liu Xinyuan, Song Peijun, Chen Qi, Yang Xiaodong, Yu Wenyuan
Department of Plastic and Cosmetic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Department of Plastic and Burn Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, 233004, China.
Curr Microbiol. 2025 Jul 24;82(9):408. doi: 10.1007/s00284-025-04390-z.
The human microbiome, including bacteria, fungi, and viruses, is widely distributed on the skin, in the oral cavity, in the gastrointestinal tract, and is also present in tumors. It is closely associated with the occurrence, development, and treatment of skin cancers and contributes to the formation of the tumor microenvironment. This review provides a detailed overview of the composition and origin of microorganisms in different types of skin tumors, focuses on the roles and mechanisms of microbiome in skin cancer, discusses their applications in the treatment of skin tumors, and outlines future research directions.
人类微生物群，包括细菌、真菌和病毒，广泛分布于皮肤、口腔、胃肠道，也存在于肿瘤中。它与皮肤癌的发生、发展和治疗密切相关，并有助于肿瘤微环境的形成。本文综述详细概述了不同类型皮肤肿瘤中微生物的组成和来源，重点阐述了微生物群在皮肤癌中的作用和机制，讨论了它们在皮肤肿瘤治疗中的应用，并概述了未来的研究方向。
