Collins A, Eneroth P, Landgren B M
Psychosom Med. 1985 Nov-Dec;47(6):512-27. doi: 10.1097/00006842-198511000-00002.
Psychoneuroendocrine stress responses were studied in normally ovulating women in the follicular, ovulatory, and luteal phases of two consecutive menstrual cycles. Psychologic stress was induced by having the subjects perform a battery of cognitive tasks under time pressure. Blood samples were drawn after each session for radioimmunoassay of 17 beta-estradiol, progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, prolactin, cortisol, and androstenedione. Urine samples were obtained for estimation of adrenaline, noradrenaline, and cortisol. The results showed that psychoneuroendocrine stress responses as estimated by urinary excretion of adrenaline and noradrenaline varied significantly across the menstrual cycle, the highest values being obtained in the luteal phase. Self-reported mood and somatic symptoms showed distinct phase-related changes, with more negative mood states predominating in the luteal and menstrual phases and increased positive mood states in the follicular and ovulatory phases.
在两个连续月经周期的卵泡期、排卵期和黄体期，对正常排卵的女性的心理神经内分泌应激反应进行了研究。通过让受试者在时间压力下完成一系列认知任务来诱发心理应激。每次测试后采集血样，用于放射免疫测定17β-雌二醇、孕酮、促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮、催乳素、皮质醇和雄烯二酮。采集尿样以测定肾上腺素、去甲肾上腺素和皮质醇。结果表明，通过尿中肾上腺素和去甲肾上腺素排泄量估计的心理神经内分泌应激反应在月经周期中差异显著，黄体期的值最高。自我报告的情绪和躯体症状显示出明显的与阶段相关的变化，黄体期和月经期以更消极的情绪状态为主，卵泡期和排卵期积极情绪状态增加。
