严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体在不同动物物种中对血管紧张素转换酶2（ACE2）受体的利用情况。
ACE2 Receptor Usage across Animal Species by SARS-CoV-2 Variants.
作者信息
Hatta Masato, Larson Gloria P, Hatta Yasuko, Wang Wei, Jiang Nannan, Jung Yu-Jin, Wang Li, Fan Xiaoyu, Calderon Brenda M, Bonenfant Gaston, Lin Xudong, Feng Chenchen, Cui Dan, Atteberry Ginger, Currier Michael, Steel John, Wentworth David E, Zhou Bin
出版信息
Emerg Infect Dis. 2025 Aug;31(8):1640-1644. doi: 10.3201/eid3108.241844.
We analyzed the receptor-binding activity and infectivity of 6 representative SARS-CoV-2 lineages in cell lines expressing angiotensin-converting enzyme 2 proteins from 54 different animal species. All viruses demonstrated infectivity in a broad range of species. Susceptible animal species could serve as natural reservoirs or intermediate hosts for SARS-CoV-2.
我们分析了6种具有代表性的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）谱系在表达来自54种不同动物物种血管紧张素转换酶2蛋白的细胞系中的受体结合活性和感染性。所有病毒在广泛的物种中均表现出感染性。易感动物物种可能作为SARS-CoV-2的天然宿主或中间宿主。
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