Cromack Sarah C, Jiang Charley, Wise Lauren A, Baird Donna D, Carnethon Mercedes R, Harmon Quaker E, Marsh Erica E, Bernardi Lia A
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Maturitas. 2025 Jul 16;200:108666. doi: 10.1016/j.maturitas.2025.108666.
To evaluate if current night shift work is associated with anti-Müllerian hormone (AMH) concentrations.
We analyzed baseline data from participants in the Study of the Environment, Lifestyle, and Fibroids (SELF), a prospective cohort study of Black women recruited 2010-2012 in metropolitan Detroit, MI. Our cohort comprised 1641 participants with serum AMH determined at baseline. AMH concentrations were used to measure ovarian reserve, i.e. the quantity of oocytes remaining in the ovary. On self-administered baseline questionnaires, participants reported whether they currently worked night shifts and, if so, how frequently. We used multivariable linear regression models to estimate percent differences and 95 % confidence intervals (CI) in mean AMH concentrations across categories of current night shift work (non-current, <1/month, ≥1/month), adjusting for covariates known to be associated with AMH concentrations (e.g., demographic factors such as age, abnormal bleeding, and contraceptive use) and baseline sleep characteristics (sleep duration, satisfaction, and efficiency).
Mean anti-Müllerian hormone concentrations.
Mean AMH concentrations were similar in the group of frequent night shift workers (n = 196, 12 %) and the group of infrequent/non-current night shift workers (n = 1445, 88 %): 4.78 ± 4.15 ng/mL vs. 5.14 ± 4.20 ng/mL. Results were similar after adjusting for potential confounders, with only a small percent difference in AMH concentrations of -8.1 % observed between the two groups (95 % CI -19.8 %, 5.4 %).
Frequent night shift work was not appreciably associated with AMH concentrations in this large cohort of reproductive-aged Black women.
评估当前的夜班工作是否与抗苗勒管激素（AMH）浓度相关。
我们分析了环境、生活方式与子宫肌瘤研究（SELF）参与者的基线数据，这是一项于2010 - 2012年在密歇根州底特律市招募黑人女性的前瞻性队列研究。我们的队列包括1641名在基线时测定了血清AMH的参与者。AMH浓度用于衡量卵巢储备，即卵巢中剩余的卵母细胞数量。在自我填写的基线问卷中，参与者报告了她们当前是否从事夜班工作，如果是，频率如何。我们使用多变量线性回归模型来估计当前夜班工作类别（非当前、<1个月、≥1个月）之间平均AMH浓度的百分比差异和95%置信区间（CI），并对已知与AMH浓度相关的协变量（如年龄、异常出血和避孕使用等人口统计学因素）以及基线睡眠特征（睡眠时间、满意度和效率）进行了调整。
平均抗苗勒管激素浓度。
频繁夜班工作组（n = 196，12%）和不频繁/非当前夜班工作组（n = 1445，88%）的平均AMH浓度相似：分别为4.78±4.15 ng/mL和5.14±4.20 ng/mL。在调整潜在混杂因素后结果相似，两组之间观察到的AMH浓度差异仅为-8.1%（95% CI -19.8%，5.4%）。
在这一大型生育年龄黑人女性队列中，频繁夜班工作与AMH浓度没有明显关联。
