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125I对人外周血淋巴细胞微核诱导的相对生物学效应。

Relative biological effectiveness of 125I in the induction of micronuclei in human peripheral blood lymphocytes.

作者信息

Kwan D K, Kagan A R, Norman A

出版信息

Radiother Oncol. 1985;4(2):163-6. doi: 10.1016/s0167-8140(85)80103-1.

DOI:10.1016/s0167-8140(85)80103-1
PMID:4070682
Abstract

The RBE for 125I relative to 30 keV X-rays, 4 MeV X-rays and 137Cs gamma rays was determined using the induction of micronuclei in human lymphocytes as the biological test system. The 125I photons were as effective as the 30 keV X-rays. If a micronuclei count of 50 per 1500 cells is used as the endpoint, the RBE for 125I was found to be about 1.8 and 1.6 when 4 MeV X-rays and 137Cs gamma rays were used as the reference radiation, respectively.

摘要

以人淋巴细胞中微核的诱导作为生物学测试系统,测定了¹²⁵I相对于30keV X射线、4MeV X射线和¹³⁷Csγ射线的相对生物效应(RBE)。¹²⁵I光子与30keV X射线的效果相同。若将每1500个细胞中50个微核的计数作为终点指标,则当分别以4MeV X射线和¹³⁷Csγ射线作为参考辐射时,¹²⁵I的RBE分别约为1.8和1.6。

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