Abtahi Seyed Mohammad Mahdi, Aghamiri Seyed Mahmoud Reza, Yadolahi Masoumeh, Mahmoudzadeh Aziz
Physics Department, Imam Khomeini International University, Norouzian, P.O. Box 34148-96818, Qazvin, Iran.
Radiation Medicine Department, University of Shahid Beheshti, Tehran, Iran.
Rep Pract Oncol Radiother. 2017 Nov-Dec;22(6):470-476. doi: 10.1016/j.rpor.2017.08.008. Epub 2017 Sep 17.
The purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose.
One of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far.
Blood samples were poured in separate vials to be irradiated at different depths using a linear accelerator system.
According to the results, MN, as a function of the absorbed dose, had the best fitness with the linear-quadratic model at all depths. Furthermore, the results showed the dependence of MN response on the depth of absorbed dose. For doses up to 2 Gy, the maximum difference from the reference depth of 1.5 cm was related to the depth of 10 cm; however, by increasing the absorbed dose, the response associated with the depth of 20 cm showed the maximum deviation from the reference depth.
Consequently, it is necessary to apply a correction factor to the biological dosimetry. The correction factor is dependent on the depth and the absorbed dose.
本研究的目的是调查微核反应对吸收剂量深度的依赖性。
用于辐射剂量测定的最常见细胞遗传学方法之一是微核（MN）。微核方法比其他方法更简单、更快，这两个显著优点使其适用于人群监测。在基于微核方法的生物剂量测定中，研究反应对剂量吸收深度的依赖性具有重要意义，尽管迄今为止受到的关注较少。
将血样倒入单独的小瓶中，使用直线加速器系统在不同深度进行照射。
根据结果，微核作为吸收剂量的函数，在所有深度下与线性二次模型的拟合度最佳。此外，结果表明微核反应对吸收剂量深度的依赖性。对于高达2 Gy的剂量，与1.5 cm参考深度的最大差异与10 cm深度有关；然而，随着吸收剂量的增加，与20 cm深度相关的反应与参考深度的偏差最大。
因此，有必要对生物剂量测定应用校正因子。校正因子取决于深度和吸收剂量。
