Chen Binglin, Xu Haifeng, Shi Yan, Cheng Minna, Chen Jia, Su Xuyan, Tang Haiying, Pan Danying, Yan Qinghua
Department of Preventive Medicine, Nanqiao Community Healthcare Center, Shanghai, China.
Department of Chronic Non-Communicable Disease, Fengxian District Center for Disease Control and Prevention, Shanghai, China.
Sci Rep. 2025 Jul 25;15(1):27017. doi: 10.1038/s41598-025-12567-6.
To characterize the associations between nighttime sleep duration and control of blood pressure (BP) and glycemia in individuals with comorbid hypertension and diabetes, we conducted a cross-sectional analysis of 2794 participants aged ≥ 50 years with confirmed diabetes and hypertension. Participants were categorized into five self-reported nighttime sleep duration groups: < 6 h, 6-7 h, 7-8 h, 8-9 h, and > 9 h. Multivariable logistic regression models were used to evaluate associations between sleep duration and BP/glycemic control, with adjustment for demographic, clinical, and behavioral confounders. We observed that prolonged sleep duration (> 9 h) was independently associated with uncontrolled BP after confounder adjustment. Subgroup analyses revealed that short sleep duration (< 6 h and 6-7 h) was linked to uncontrolled BP among males, whereas prolonged sleep duration was associated with uncontrolled BP among females, participants under 65 years, those with regular medication adherence, and non-nappers. For glycemic control, prolonged sleep duration conferred a protective effect among normal-weight individuals, but this association was not evident in the overall sample. Our results suggested that BP regulation may play a dominant role in competitive metabolic regulation demands compared to glycemic regulation. We recommended that individualized interventions aimed at modifying the habitual sleep duration of patients with comorbidities may be a crucial strategy to enhance BP and blood glucose management.
为了描述合并高血压和糖尿病患者夜间睡眠时间与血压（BP）及血糖控制之间的关联，我们对2794名年龄≥50岁、确诊患有糖尿病和高血压的参与者进行了横断面分析。参与者被分为五个自我报告的夜间睡眠时间组：<6小时、6 - 7小时、7 - 8小时、8 - 9小时和>9小时。使用多变量逻辑回归模型评估睡眠时间与血压/血糖控制之间的关联，并对人口统计学、临床和行为混杂因素进行了调整。我们观察到，在调整混杂因素后，睡眠时间延长（>9小时）与血压未得到控制独立相关。亚组分析显示，短睡眠时间（<6小时和6 - 7小时）与男性血压未得到控制有关，而睡眠时间延长与女性、65岁以下参与者、规律服药者和不午睡者的血压未得到控制有关。对于血糖控制，睡眠时间延长在正常体重个体中具有保护作用，但在总体样本中这种关联并不明显。我们的结果表明，与血糖调节相比，血压调节可能在竞争性代谢调节需求中起主导作用。我们建议，针对合并症患者习惯性睡眠时间进行调整的个体化干预可能是加强血压和血糖管理的关键策略。
