Lanas A, Alcalde J, Montoro M, Gomollon F, Morandeira J, Bueno J, Sainz R
Rev Esp Fisiol. 1985 Sep;41(3):335-9.
Gastrin serum levels after acidification of the second portion of the duodenum were studied, in dogs and humans, while simultaneously measuring secretin levels and gastric acid secretion. After duodenal acidification in dogs, a 50% inhibition of gastric acid secretion with parallel 100% increases in the serum secretin levels was noted whereas gastrin serum levels did not change (after duodenal acidification). In humans, a 25% inhibition of gastric acid secretion with parallel 50% (not significative) increases in the secretin serum levels was noted. In the entire group gastrin levels did not change, but in 35.2% of the subjects a little increment without statistical significance was noted. It is concluded that the inhibition mechanism of gastric acid secretion after duodenal acidification is more important in dog than in man, and that, probably, gastrin does not play an important role in this mechanism.
在狗和人类身上研究了十二指肠第二部酸化后的血清胃泌素水平，同时测量促胰液素水平和胃酸分泌。狗十二指肠酸化后，胃酸分泌受到50%的抑制，血清促胰液素水平同时升高100%，而血清胃泌素水平没有变化（十二指肠酸化后）。在人类中，胃酸分泌受到25%的抑制，血清促胰液素水平同时升高50%（无统计学意义）。在整个研究组中，胃泌素水平没有变化，但在35.2%的受试者中观察到略有升高，但无统计学意义。得出的结论是，十二指肠酸化后胃酸分泌的抑制机制在狗身上比在人类身上更重要，并且胃泌素可能在该机制中不发挥重要作用。
