Miyata M, Rayford P L, Thompson J C
Surgery. 1980 Feb;87(2):209-15.
We have studied the influences of duodenal acidification on the effects of bombesin on gastric and pancreatic secretion and on blood levels of gastrin, secretin, and cholecystokinin (CCK) in six conscious dogs with chronic gastric and pancreatic fistulas. Duodenal acidification suppressed bombesin-stimulated gastric acid output (from 20.1 +/- 4.2 to 8.2 +/- 1.9 mEq/120 min) and gastrin release (from an integrated 2-hour output of 16.0 +/- 1.2 to 11.1 +/- 1.1 ng-min/ml). On the other hand, duodenal acidification augmented bombesin-stimulated secretion of pancreatic bicarbonate (from 0.75 +/- 0.12 to 7.81 +/- 2.0 mEq/120 min) and protein (from 0.57 +/- 0.10 to 1.00 +/- 0.18 gm/120 min). Blood levels of CCK (but not of secretin) were increased with bombesin alone, whereas blood levels of secretin (but not CCK) were increased by duodenal acidification alone. Bombesin plus duodenal acidification resulted in increase of both CCK and secretin. This increase of secretin may be responsible, in part, for suppression of both gastric acid output and gastrin release, as well as for increases in pancreatic secretion of bicarbonate and protein.
我们研究了十二指肠酸化对蛙皮素对胃和胰腺分泌的影响以及对六只患有慢性胃瘘和胰腺瘘的清醒犬胃泌素、促胰液素和胆囊收缩素（CCK）血药浓度的影响。十二指肠酸化抑制了蛙皮素刺激的胃酸分泌（从20.1±4.2降至8.2±1.9毫当量/120分钟）和胃泌素释放（从2小时综合分泌量16.0±1.2降至11.1±1.1纳克-分钟/毫升）。另一方面，十二指肠酸化增强了蛙皮素刺激的胰腺碳酸氢盐分泌（从0.75±0.12增至7.81±2.0毫当量/120分钟）和蛋白质分泌（从0.57±0.10增至1.00±0.18克/120分钟）。单独使用蛙皮素可使CCK血药浓度升高（促胰液素血药浓度未升高），而单独进行十二指肠酸化可使促胰液素血药浓度升高（CCK血药浓度未升高）。蛙皮素加十二指肠酸化导致CCK和促胰液素均升高。促胰液素的这种升高可能部分导致了胃酸分泌和胃泌素释放的抑制，以及胰腺碳酸氢盐和蛋白质分泌的增加。
