Lin Shih-Ho, Hsu Shan-Hui
Institute of Polymer Science and Engineering, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei, 106319, Taiwan, ROC.
J Biomed Sci. 2025 Jul 24;32(1):70. doi: 10.1186/s12929-025-01166-2.
The application of smart hydrogels has become a booming research frontier in biomedical engineering. With the development of intelligent drug delivery systems, various biomimetic and biodegradable hydrogels are employed for localized drug delivery to tissues in the preclinical applications. These advanced materials are designed to match the diverse environmental and functional requirements of various tissue types and organs. This article discusses the attractive characteristics of smart hydrogels as delivery systems and reviews the design of a range of smart hydrogels, as well as the challenges of tissue-specific drug delivery, focusing on the last 5 years of frontward research.
智能水凝胶的应用已成为生物医学工程中一个蓬勃发展的研究前沿领域。随着智能药物递送系统的发展，各种仿生和可生物降解水凝胶被用于临床前应用中向组织的局部药物递送。这些先进材料的设计旨在满足各种组织类型和器官的不同环境及功能需求。本文讨论了智能水凝胶作为递送系统的诱人特性，回顾了一系列智能水凝胶的设计，以及组织特异性药物递送面临的挑战，重点关注过去5年的前沿研究。
