Ding Kaidi, Zhang Yaocheng, Liu Ying, Liu Chuntai, Ma Yuhong, Shen Changyu
Key Laboratory of Materials Processing and Mold (Zhengzhou University), Ministry of Education, National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 450002, China.
College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Langmuir. 2025 Aug 5;41(30):20144-20153. doi: 10.1021/acs.langmuir.5c02384. Epub 2025 Jul 24.
Bacteria adhesion, which forms biofilms with multicellular structures on the surfaces of various medical devices, can result in severe infections and even patient mortality. Here, we develop an effective antifouling and antibacterial coating for poly(vinyl chloride) (PVC) substrates. Specifically, the coating is fabricated with anionic polysaccharide hyaluronic acid (HA) and cationic quaternized ,-dimethylethylenediamine (QDED). The strong hydration capacity of HA significantly reduces the water contact angle of the modified PVC surfaces from 101.4° to 25.4°, enhancing their antifouling performance, while QDED provides direct bactericidal effects. This synergistic combination exhibits robust resistance to both bacterial adhesion and biofilm formation, as demonstrated by extracorporeal circulation and static biofilm resistance assays, better aligning with long-term clinical requirements. This study presents a simple and effective method for modifying PVC surfaces to achieve antifouling and antibacterial properties without compromising biocompatibility, thereby offering potential applications in biomedical devices.
细菌粘附会在各种医疗设备表面形成具有多细胞结构的生物膜，可导致严重感染甚至患者死亡。在此，我们开发了一种用于聚氯乙烯（PVC）基材的有效防污抗菌涂层。具体而言，该涂层由阴离子多糖透明质酸（HA）和阳离子季铵化的N,N-二甲基乙二胺（QDED）制成。HA的强水合能力显著降低了改性PVC表面的水接触角，从101.4°降至25.4°，增强了其防污性能，而QDED具有直接杀菌作用。体外循环和静态生物膜抗性试验表明，这种协同组合对细菌粘附和生物膜形成均具有强大的抗性，更符合长期临床需求。本研究提出了一种简单有效的方法来修饰PVC表面，以实现防污抗菌性能而不损害生物相容性，从而在生物医学设备中具有潜在应用。
