St John W M, Bledsoe T A
Respir Physiol. 1985 Oct;62(1):61-78. doi: 10.1016/0034-5687(85)90050-7.
In decerebrate, paralyzed and vagotomized cats, we recorded activities of hypoglossal and phrenic nerves and of the mylohyoid branch of the trigeminal nerve. At normocapnia, a respiratory-modulated trigeminal discharge could be discerned in most cats. This discharge was characterized by a diminution of activity during neural inspiration and a peak in expiration. In hypercapnia or hypoxia, peak activity increased and its time of occurrence moved to late inspiration. Augmentations of peak trigeminal, hypoglossal and phrenic activities were proportional. Peak trigeminal and hypoglossal activities increased more than phrenic following administrations of protriptyline, strychnine and, in some cats, cyanide or doxapram. Peak trigeminal activity fell more than phrenic after diazepam. Pentobarbital or halothane reduced peak hypoglossal, but not trigeminal, activity more than phrenic. However, after these anesthetics, trigeminal activity became restricted to the inspiratory-expiratory junction. We conclude that trigeminal and hypoglossal activities are more dependent upon processes within the reticular formation than is the bulbospinal-phrenic system. Central and peripheral chemoreceptor influences are distributed equivalently upon trigeminal, hypoglossal and phrenic motoneurons.
在去大脑、瘫痪并切断迷走神经的猫身上，我们记录了舌下神经、膈神经以及三叉神经下颌舌骨肌支的活动。在正常二氧化碳分压时，多数猫可辨别出呼吸调制的三叉神经放电。这种放电的特征是在神经吸气时活动减弱，呼气时达到峰值。在高碳酸血症或低氧血症时，峰值活动增加，且其出现时间移至吸气后期。三叉神经、舌下神经和膈神经峰值活动的增强是成比例的。给予丙咪嗪、士的宁以及在某些猫中给予氰化物或多沙普仑后，三叉神经和舌下神经的峰值活动比膈神经增加得更多。地西泮给药后，三叉神经峰值活动比膈神经下降得更多。戊巴比妥或氟烷对舌下神经峰值活动的降低比对膈神经和三叉神经的降低更明显。然而，使用这些麻醉剂后，三叉神经活动局限于吸气 - 呼气交界处。我们得出结论，与延髓脊髓 - 膈神经系统相比，三叉神经和舌下神经活动更依赖于网状结构内的过程。中枢和外周化学感受器的影响在三叉神经、舌下神经和膈神经运动神经元上的分布是等效的。
