St John W M
Respir Physiol. 1986 Oct;66(1):27-40. doi: 10.1016/0034-5687(86)90136-2.
Studies were undertaken to evaluate the hypothesis that mechanisms within the reticular formation influence activities of nerves to muscles of the upper airways more than the bulbospinal-phrenic system. In decerebrate, vagotomized, paralyzed and ventilated cats, activities of the phrenic, trigeminal, and the hypoglossal nerves were monitored. Activity of the pontile and medullary reticular formation was increased directly by electrical stimulation within the brainstem and indirectly by stimulating the sciatic nerve. Trigeminal and hypoglossal discharges increased more than phrenic during stimulations at many brainstem loci. Changes were typically maintained for one or more respiratory cycles following termination of stimulation. At some loci, activation of neurons by microinjections of glutamate increased trigeminal and hypoglossal activities more than phrenic. Although responses were extremely variable, activities of the trigeminal and/or hypoglossal nerves usually increased more than phrenic during stimulations of the sciatic nerve or upon termination of stimulation. The results support the conclusion that respiratory-modulated trigeminal and hypoglossal discharges are dependent upon reticular mechanisms for their expression.
开展了多项研究，以评估以下假说：网状结构内的机制对支配上呼吸道肌肉的神经活动的影响，比延髓脊髓 - 膈神经系统更大。在去大脑、切断迷走神经、麻痹并通气的猫身上，监测膈神经、三叉神经和舌下神经的活动。通过脑干内的电刺激直接增加脑桥和延髓网状结构的活动，并通过刺激坐骨神经间接增加其活动。在许多脑干位点进行刺激时，三叉神经和舌下神经的放电增加幅度比膈神经更大。刺激终止后，变化通常会在一个或多个呼吸周期内持续存在。在某些位点，通过微量注射谷氨酸激活神经元，对三叉神经和舌下神经活动的增加幅度比对膈神经更大。尽管反应变化极大，但在刺激坐骨神经期间或刺激终止后，三叉神经和/或舌下神经的活动通常比膈神经增加得更多。这些结果支持以下结论：呼吸调节的三叉神经和舌下神经放电在表达上依赖于网状机制。
