St John W M
Exp Neurol. 1987 Aug;97(2):301-14. doi: 10.1016/0014-4886(87)90091-4.
The influence of the pneumotaxic center on activities of the phrenic, hypoglossal, and trigeminal nerves was investigated in decerebrate, vagotomized, paralyzed, and ventilated cats. Stimulation of the pneumotaxic region caused a premature termination of activity of the phrenic nerve. Currents required for terminating this activity decreased during inspiration. Inspiratory hypoglossal and trigeminal activities were terminated concomitant with phrenic activity. The expiratory duration following stimulus-induced cessation of inspiration was directly related to inspiratory duration. During expiration, trigeminal activity was greatly augmented; a hypoglossal burst was also recorded in some trials. Stimulations in expiration elicited premature onsets of phrenic, hypoglossal, and trigeminal activities. The currents required declined during expiration. The durations of neural inspiration and expiration and peak phrenic and hypoglossal activities which followed stimulus-induced terminations of expiration approximated prestimulation values. Phasic trigeminal and expiratory hypoglossal activities were greatly augmented. Currents required for terminating either inspiratory or expiratory phases were augmented in hypercapnia. The data support pneumotaxic mechanisms as producing global onsets or terminations of inspiratory activity. Respiratory motoneurons of the brain stem and spinal cord differ in their sensitivities to efferent influences from the pneumotaxic center.
在去大脑、切断迷走神经、麻痹并通气的猫身上，研究了呼吸调节中枢对膈神经、舌下神经和三叉神经活动的影响。刺激呼吸调节区域会导致膈神经活动提前终止。在吸气过程中，终止这种活动所需的电流会降低。吸气时的舌下神经和三叉神经活动会与膈神经活动同时终止。刺激诱发吸气停止后的呼气持续时间与吸气持续时间直接相关。在呼气过程中，三叉神经活动大大增强；在一些试验中还记录到舌下神经爆发。在呼气时进行刺激会引发膈神经、舌下神经和三叉神经活动的提前开始。所需电流在呼气过程中下降。刺激诱发呼气停止后，神经吸气和呼气的持续时间以及膈神经和舌下神经活动的峰值接近刺激前的值。相位性三叉神经和呼气时的舌下神经活动大大增强。在高碳酸血症时，终止吸气或呼气阶段所需的电流会增加。这些数据支持呼吸调节机制可产生吸气活动的整体开始或终止。脑干和脊髓的呼吸运动神经元对来自呼吸调节中枢的传出影响的敏感性不同。
