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放血对大鼠器官重量的影响。

The effect of exsanguination on organ weight of rats.

作者信息

Sullivan D J

出版信息

Toxicol Pathol. 1985;13(3):229-31. doi: 10.1177/019262338501300310.

DOI:10.1177/019262338501300310
PMID:4070933
Abstract

In three experiments, rats were anesthetized and killed by exsanguination or were killed by an overdose of anesthetic and not exsanguinated. The second group of rats in each experiment mimicked rats found dead on toxicology studies. Liver and kidney weights of rats killed by exsanguination were statistically significantly lower than those of rats not exsanguinated both in terms of gross organ weight and of percentage of body weight. The results of these experiments indicate that organ weight data of rats killed by exsanguination should be segregated from those of rats found dead. In fact, because of uncontrollable variables, organs of rats found dead should not be weighed.

摘要

在三个实验中,大鼠通过放血进行麻醉并致死,或者通过过量麻醉剂致死且不放血。每个实验中的第二组大鼠模拟毒理学研究中发现的死亡大鼠。放血致死的大鼠的肝脏和肾脏重量,无论在器官总重量还是体重百分比方面,在统计学上均显著低于未放血的大鼠。这些实验结果表明,放血致死的大鼠的器官重量数据应与发现死亡的大鼠的器官重量数据分开。实际上,由于存在无法控制的变量,不应称量发现死亡的大鼠的器官重量。

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