Frasca P, Buchanan J W, Soriano R Z, Dunn J M, Marmon L, Melbin J, Buchanan S J, Golub E E, Shapiro I M
Scan Electron Microsc. 1985(Pt 3):1253-8.
Pericardial patch grafts were implanted in the hearts of young sheep for periods ranging from two to 120 days. Explants seven to 21 days old revealed the formation of a "pseudoneointima" (PNI) on the blood contacting surface of the pericardium. The PNI was more heavily mineralized than the pericardium. Mineralization was most intense on the blood contacting surface of the PNI and on the chamber surface of the pericardium. After three weeks of implantation, the PNI was much thinner and was organized into a thin fibrous capsule without any signs of mineralization. In the pericardium, mineral deposits were seen in fibroblasts. Moreover, cell-related mineralization was evident prior to calcification of the surrounding collagen matrix.
将心包补片移植到幼羊心脏中，植入时间为2至120天。7至21天大的外植体显示在心包与血液接触的表面形成了“假内膜”（PNI）。PNI的矿化程度比心包更严重。矿化在PNI与血液接触的表面以及心包的心腔表面最为强烈。植入三周后，PNI变薄很多，并组织成一层薄的纤维囊，没有任何矿化迹象。在心包中，在成纤维细胞中可见矿物质沉积。此外，在周围胶原基质钙化之前，细胞相关矿化就很明显。
