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子宫颈大细胞神经内分泌癌伴双相突触素染色模式及阴道上皮内复发：一例报告

Large Cell Neuroendocrine Carcinoma of the Uterine Cervix With a Biphasic Synaptophysin Staining Pattern and Followed Vaginal Intraepithelial Recurrence: A Case Report.

作者信息

Toyoda Shinji, Morita Kohei, Ito Fuminori, Niiro Emiko, Taniguchi Makiko, Sado Toshiyuki

机构信息

Department of Obstetrics and Gynecology, Nara Prefecture General Medical Center, Nara, Japan.

Department of Diagnostic Pathology, Nara Prefecture General Medical Center, Nara, Japan.

出版信息

Cytopathology. 2025 Nov;36(6):602-605. doi: 10.1111/cyt.70012. Epub 2025 Jul 25.

DOI:10.1111/cyt.70012
PMID:40709737
Abstract

This case highlights the importance of early, aggressive surgery for large cell neuroendocrine carcinoma and continuous cytological monitoring in detecting recurrence at the early intraepithelial stage. The pagetoid spread pattern with a biphasic synaptophysin staining differentiated LCNEC from CIN3 and AIS.

摘要

该病例凸显了对大细胞神经内分泌癌进行早期积极手术以及在早期上皮内阶段检测复发时进行持续细胞学监测的重要性。伴有双相突触素染色的派杰样扩散模式将大细胞神经内分泌癌与CIN3和原位腺癌区分开来。

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