激活Nrf2信号通路作为牙周病治疗策略的叙述性综述
Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review.
作者信息
Saha Sarmistha, Sachivkina Nadezhda, Lenchenko Ekaterina, Pilshchikova Olga, Muraev Alexandr
机构信息
Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura 281406, Uttar Pradesh, India.
Department of Microbiology V.S. Kiktenko, Institute of Medicine, Peoples' Friendship University of Russia Named After Patrice Lumumba (RUDN University), 117198 Moscow, Russia.
出版信息
Dent J (Basel). 2025 Jul 11;13(7):314. doi: 10.3390/dj13070314.
Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing the relationship between inflammation and oxidative stress, making it vital for understanding this disease. Nrf2 interacts with key redox-sensitive inflammatory pathways, playing a vital role in the development of periodontitis. Acknowledging these dynamics underscores the importance of proactively addressing the complex aspects of periodontal disease. This review emphasizes its intricate interactions with redox-sensitive transcription factors vital for sustaining the self-perpetuating inflammatory processes underlying the disease. Additionally, it explores promising therapeutic strategies aimed at Nrf2 activation and encourages more effective management of PD.
牙周炎（PD）是一种牙周系统的慢性炎症性疾病，该系统包括牙龈、牙周韧带、牙槽骨和牙骨质。它在全球范围内日益普遍，对口腔健康的影响深远。Nrf2信号通路在炎症与氧化应激之间的关系管理中至关重要，这使其对于理解这种疾病至关重要。Nrf2与关键的氧化还原敏感炎症途径相互作用，在牙周炎的发展中发挥着至关重要的作用。认识到这些动态变化凸显了积极应对牙周疾病复杂方面的重要性。本综述强调了其与氧化还原敏感转录因子的复杂相互作用，这些转录因子对于维持该疾病潜在的自我持续炎症过程至关重要。此外，它还探讨了旨在激活Nrf2的有前景的治疗策略，并鼓励更有效地管理牙周炎。
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