Lazcano Catherine Sarre, Gronchi Alessandro
Division of Surgical Oncology, Department of Surgery, University of Toronto, Toronto, ON M5S 1A1, Canada.
Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Curr Oncol. 2025 Jul 18;32(7):408. doi: 10.3390/curroncol32070408.
Desmoid tumors are rare, deep-seated myofibroblastic tumors with an unpredictable course, ranging from spontaneous regression to infiltrative growth and locally aggressive behavior, but without metastatic potential. Over the past few decades, advances in understanding their natural history, underlying molecular pathways, and patient care priorities have shifted the treatment paradigm from upfront surgical resection to initial active surveillance, with further treatment dictated by continuous disease progression or associated symptoms. However, there are still specific scenarios where surgery continues to play an important role in locoregional treatment and symptom control. This article will focus on current treatment strategies and surgical indications in adult patients with desmoid tumors, emphasizing patient selection, anatomic site-specific considerations, and surgical technique. Understanding the nuanced role of surgery within the growing treatment landscape is key for individualized patient care in a multidisciplinary setting to optimize quality of life and long-term outcomes.
硬纤维瘤是一种罕见的深部肌成纤维细胞肿瘤，病程难以预测，从自发消退到浸润性生长和局部侵袭性生长，但无转移潜能。在过去几十年里，对其自然史、潜在分子途径和患者护理重点的认识进展已将治疗模式从 upfront 手术切除转变为初始主动监测，进一步的治疗取决于疾病的持续进展或相关症状。然而，在某些特定情况下，手术在局部区域治疗和症状控制中仍发挥着重要作用。本文将重点关注成年硬纤维瘤患者的当前治疗策略和手术指征，强调患者选择、解剖部位特异性考虑因素和手术技术。了解手术在不断发展的治疗格局中的细微作用，是在多学科环境中进行个体化患者护理以优化生活质量和长期预后的关键。
