Gwatkin R B, Williams D T, Carlo D J
Fertil Steril. 1977 Aug;28(8):871-7. doi: 10.1016/s0015-0282(16)42744-5.
Immunization of female mice with heat-solubilized hamster zonae pellucidae resulted in the production of antibody specific for the zona pellucida of several species, including that of primates. Complete, although temporary, infertility was produced in the mice. The zonae of ovulated eggs from the immune mice were found to contain antibody and complement. Many also appeared abnormal, but no apparent effect was observed on either vitelli or any of the other tissues that were examined. These results suggest the feasibility of developing a zona vaccine for contraception.
用热溶解的仓鼠透明带对雌性小鼠进行免疫，可产生针对包括灵长类动物在内的几种物种透明带的特异性抗体。这些小鼠出现了完全但暂时的不育。发现免疫小鼠排出的卵子的透明带含有抗体和补体。许多透明带也显得异常，但对所检查的卵黄或任何其他组织均未观察到明显影响。这些结果表明开发一种用于避孕的透明带疫苗是可行的。
