人类与狨猴透明带之间的抗原交叉反应性，免疫避孕的一个潜在靶点。

Antigenic cross-reactivity between human and marmoset zonase pellucidae, a potential target for immunocontraception.

作者信息

Shivers C A, Gengozian N, Franklin S, McLaughlin C L

出版信息

J Med Primatol. 1978;7(4):242-8. doi: 10.1159/000459885.

Abstract

Cross-reactivity between marmoset, chimpanzee, human and pig zona pellucida antigens was demonstrated by immunofluorescence and zona precipitation. In marmosets, anti-zona antibody prevented sperm attachment to eggs in vitro, and the antibody could be detected on zonae of ovarian oocytes following passive immunization. Use of the marmoset as an animal model in testing feasibility of the zona approach to immunocontraception is discussed.

摘要

通过免疫荧光和透明带沉淀法证明了狨猴、黑猩猩、人类和猪的透明带抗原之间存在交叉反应。在狨猴中，抗透明带抗体在体外可阻止精子附着于卵子，并且在被动免疫后可在卵巢卵母细胞的透明带上检测到该抗体。文中讨论了将狨猴用作动物模型来测试透明带免疫避孕方法的可行性。