Mishra Akash, Tostaeva Gelana, Nentwich Maximilian, Espinal Elizabeth, Markowitz Noah, Winfield Jalen, Freund Elisabeth, Gherman Sabina, Leszczynski Marcin, Schroeder Charles E, Mehta Ashesh D, Bickel Stephan
The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Departments of Neurosurgery and Neurology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Sci Adv. 2025 Jul 25;11(30):eadv0986. doi: 10.1126/sciadv.adv0986.
The discrete events of our narrative experience are organized by the neural substrate that underlies episodic memory. This narrative process is segmented into distinct units by event boundaries, which facilitate a replay process that acts to consolidate each event into a narrative memory. High-frequency oscillations (HFOs) may synchronize neural activity during these processes. We use intracranial recordings from participants viewing and freely recalling a continuous, audiovisual stimulus. We find that hippocampal HFOs increase following event boundaries and hippocampal-cortical coincident HFOs (co-HFOs) occur in cortical regions that underlie event segmentation (inferior parietal, precuneus, lateral occipital, and inferior frontal cortices). Event-specific co-HFO patterns that occur during event viewing reoccur following event boundaries for the subsequent three events and during recall. This is consistent with models that support replay as a mechanism for memory consolidation. Therefore, HFOs may coordinate activity across brain regions that facilitate event segmentation, encode memory of discrete events, and bind representations to assemble memory of a coherent, continuous experience.
我们叙事体验中的离散事件由情景记忆背后的神经基质组织起来。这个叙事过程通过事件边界被分割成不同的单元，这些边界促进了一个重放过程，该过程将每个事件巩固为叙事记忆。高频振荡（HFOs）可能在这些过程中使神经活动同步。我们使用参与者观看并自由回忆连续视听刺激时的颅内记录。我们发现，事件边界之后海马体的HFOs增加，并且在构成事件分割基础的皮质区域（顶下小叶、楔前叶、枕外侧皮质和额下皮质）会出现海马体 - 皮质同步高频振荡（co - HFOs）。在事件观看期间出现的特定于事件的co - HFO模式，在随后的三个事件的事件边界之后以及回忆期间再次出现。这与支持重放作为记忆巩固机制的模型一致。因此，HFOs可能协调大脑区域之间的活动，这些活动有助于事件分割、编码离散事件的记忆，并将表征结合起来以组装连贯、连续体验的记忆。
