Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.
Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, USA.
Nat Hum Behav. 2024 Oct;8(10):1988-2002. doi: 10.1038/s41562-024-01952-2. Epub 2024 Aug 12.
Whether high-frequency phase-locked oscillations facilitate integration ('binding') of information across widespread cortical areas is controversial. Here we show with intracranial electroencephalography that cortico-cortical co-ripples (~100-ms-long ~90 Hz oscillations) increase during reading and semantic decisions, at the times and co-locations when and where binding should occur. Fusiform wordform areas co-ripple with virtually all language areas, maximally from 200 to 400 ms post-word-onset. Semantically specified target words evoke strong co-rippling between wordform, semantic, executive and response areas from 400 to 800 ms, with increased co-rippling between semantic, executive and response areas prior to correct responses. Co-ripples were phase-locked at zero lag over long distances (>12 cm), especially when many areas were co-rippling. General co-activation, indexed by non-oscillatory high gamma, was mainly confined to early latencies in fusiform and earlier visual areas, preceding co-ripples. These findings suggest that widespread synchronous co-ripples may assist the integration of multiple cortical areas for sustained periods during cognition.
高频锁相振荡是否有助于广泛皮质区域的信息整合（“绑定”）存在争议。在这里，我们通过颅内脑电图显示，在阅读和语义决策期间，当且仅当发生绑定时，皮质间共锐波（100ms 长90Hz 振荡）增加。梭状回单词形式区域与几乎所有语言区域共锐波，在单词出现后 200 到 400 毫秒达到最大值。语义指定的目标词在单词形式、语义、执行和反应区域之间从 400 到 800 毫秒引起强烈的共锐波，在正确反应之前，语义、执行和反应区域之间的共锐波增加。共锐波在长距离（>12cm）上以零延迟锁相，尤其是当许多区域共锐波时。广泛的同步共锐波可能有助于在认知过程中持续整合多个皮质区域，这一点通过非振荡高伽马索引的一般共激活来表示，主要局限于梭状回和更早的视觉区域的早期潜伏期，先于共锐波。这些发现表明，广泛的同步共锐波可能有助于在认知过程中持续整合多个皮质区域。
