Higuchi M, Abe K
Spine (Phila Pa 1976). 1985 Sep;10(7):638-43. doi: 10.1097/00007632-198509000-00008.
The nucleus pulposus of the lumbar intervertebral disc of mice given daily intramuscular injection of hydrocortisone at a dose of 1, 5, 10 mg/kg body weight for 1-4 weeks from 2 weeks of age was studied by electron microscopy. The hydrocortisone administration induced degeneration of the notochordal cells in the nucleus pulposus. The degenerative changes occurred earlier in the periphery of the nucleus pulposus than in the central region and developed earlier in mice treated with higher doses of hydrocortisone than in mice treated with lower doses. From the results, it is likely that steroid treatment accelerates the aging process of the nucleus pulposus and causes dysfunction of the intervertebral disc.
从2周龄开始，对每日肌肉注射剂量为1、5、10mg/kg体重氢化可的松，持续1 - 4周的小鼠腰椎间盘髓核进行了电子显微镜研究。给予氢化可的松导致髓核中脊索细胞变性。变性变化在髓核周边比在中央区域出现得更早，并且在高剂量氢化可的松处理的小鼠中比在低剂量处理的小鼠中发展得更早。从结果来看，类固醇治疗可能会加速髓核的老化过程并导致椎间盘功能障碍。
