复合膳食抗氧化指数与肺癌风险：来自英国生物银行的见解

Composite dietary antioxidant index and lung cancer risk: insights from the UK biobank.

作者信息

Feng Yi, Fu Xiuxia, Cheng Bo, Chen Peiling, Wang Zixun, He Juan, Zheng Xiangyuan, Wu Xinyi, Bi Xin, Dong Minyu, He Jianxing, Liang Wenhua

机构信息

Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.

Guangzhou Institute of Respiratory Health, Guangzhou, 510120, China.

出版信息

BMC Public Health. 2025 Jul 26;25(1):2560. doi: 10.1186/s12889-025-23720-1.

DOI:10.1186/s12889-025-23720-1

PMID:40713554

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12297808/

Abstract

BACKGROUND

Previous studies provided inconsistent results on the effects of antioxidant intake on lung cancer prevention. This study aimed to investigate the association between the composite dietary antioxidant index (CDAI), which calculated the dietary intake of manganese, selenium, zinc, vitamins A, C and E, and the risk of lung cancer.

METHODS

Using prospective data from the UK Biobank, this study employed Cox proportional hazards regression models to evaluate the relationship between CDAI and lung cancer risk, and restricted cubic spline analyses were used to explore potential nonlinear associations. Multiplicative and additive interaction analyses were conducted to assess the joint effects of CDAI and smoking status on lung cancer risk.

RESULTS

Among 201,316 participants over a median follow-up of 11.8 years, 1,229 new cases of lung cancer were identified. Multivariate analysis showed that participants in the highest quartile of CDAI had a significantly lower risk of lung cancer (HR: 0.70; 95% CI: 0.57-0.86; P < 0.001), compared with those in the lowest quartile. An interaction effect between CDAI and smoking status was noted (P = 0.001). Among former smokers, the hazard ratio was 4.58 (95% CI: 3.36-6.25; P = 8.42 × 10⁻) in the lowest CDAI quartile and decreased to 2.60 (95% CI: 1.83-3.70; P = 1.10 × 10⁻⁷) in the highest quartile, compared to never smokers in the lowest CDAI quartile.

CONCLUSION

This study revealed a significant link between increased dietary antioxidant intake and a reduced risk of lung cancer, particularly in former smokers.

摘要

背景

以往研究关于抗氧化剂摄入对肺癌预防的影响结果并不一致。本研究旨在调查综合膳食抗氧化指数（CDAI，该指数计算了锰、硒、锌、维生素A、C和E的膳食摄入量）与肺癌风险之间的关联。

方法

利用英国生物银行的前瞻性数据，本研究采用Cox比例风险回归模型评估CDAI与肺癌风险之间的关系，并使用受限立方样条分析来探索潜在的非线性关联。进行乘法和加法交互分析以评估CDAI和吸烟状态对肺癌风险的联合作用。

结果

在201,316名参与者中，中位随访时间为11.8年，共确诊1,229例新发肺癌病例。多变量分析显示，与CDAI最低四分位数组的参与者相比，CDAI最高四分位数组的参与者患肺癌的风险显著降低（风险比：0.70；95%置信区间：0.57 - 0.86；P < 0.001）。注意到CDAI与吸烟状态之间存在交互作用（P = 0.001）。在既往吸烟者中，CDAI最低四分位数组的风险比为4.58（95%置信区间：3.36 - 6.25；P = 8.42×10⁻），与CDAI最低四分位数组的从不吸烟者相比，最高四分位数组的风险比降至2.60（95%置信区间：1.83 - 3.70；P = 1.10×10⁻⁷）。