Liu Xinyi, Zhang Xiaoyang, Gong Chen, Hu Haiou, Qiao Zhiyu, Li Chengnan, Ge Yipeng, Zhu Junming
Department of Cardiovascular Surgery, Beijing Aortic Disease Center Beijing Anzhen Hospital of Capital Medical University Beijing China.
Department of Hematology Beijing Anzhen Hospital of Capital Medical University Beijing China.
J Am Heart Assoc. 2025 Jun 17;14(12):e040481. doi: 10.1161/JAHA.124.040481. Epub 2025 Jun 4.
Shift work is associated with various health problems, but its impact on aortic aneurysm (AA) is unclear. The role of lifestyle factors in this regard is also less clear. This study aimed to explore the combined effects of shift work and lifestyle on AA risk.
A total of 213971 employed or self-employed participants from the UK Biobank were included in the study. Employment and lifestyle information was collected. Cox proportional hazards regression models were applied to assess the association between shift work and AA. Restricted cubic spline functions, mediation, interaction, and joint analyses were used to further explore the relationship between unhealthy lifestyle, shift work, and AA risk.
Among 213 971 participants, 1035 developed AA during a mean follow-up of 14.9 years. In fully adjusted models, shift work was associated with a significantly higher risk of AA (hazard ratio [HR], 1.24 [95% CI, 1.06-1.46]), with frequent shift workers showing an elevated risk (HR, 1.27 [95% CI, 1.03-1.57]). A dose-dependent relationship was observed between the unhealthy lifestyle score and the risk of AA, with the risk of AA increasing as the unhealthy lifestyle score increased. The joint effect of shift work and unhealthy lifestyle showed a significant association, particularly among shift workers with 4 to 5 unhealthy lifestyle factors (HR, 2.26 [95% CI, 1.63-3.14]).
In this cohort study, we found that shift work was significantly associated with an increased risk of AA. Additionally, unhealthy lifestyles, particularly smoking, may play a crucial role in this association. These findings underscore the need for targeted prevention strategies, especially for shift workers with unhealthy lifestyle factors.
轮班工作与多种健康问题相关，但其对主动脉瘤（AA）的影响尚不清楚。生活方式因素在这方面的作用也不太明确。本研究旨在探讨轮班工作和生活方式对AA风险的综合影响。
本研究纳入了英国生物银行的213971名受雇或自营职业参与者。收集了就业和生活方式信息。应用Cox比例风险回归模型评估轮班工作与AA之间的关联。使用受限立方样条函数、中介分析、交互分析和联合分析进一步探讨不健康生活方式、轮班工作与AA风险之间的关系。
在213971名参与者中，1035人在平均14.9年的随访期间发生了AA。在完全调整模型中，轮班工作与AA风险显著升高相关（风险比[HR]，1.24[95%CI，1.06 - 1.46]），频繁轮班工作者的风险更高（HR，1.27[95%CI，1.03 - 1.57]）。观察到不健康生活方式评分与AA风险之间存在剂量依赖关系，随着不健康生活方式评分的增加，AA风险增加。轮班工作和不健康生活方式的联合效应显示出显著关联，特别是在具有4至5个不健康生活方式因素的轮班工作者中（HR，2.26[95%CI，1.63 - 3.14]）。
在这项队列研究中，我们发现轮班工作与AA风险增加显著相关。此外，不健康的生活方式，尤其是吸烟，可能在这种关联中起关键作用。这些发现强调了制定针对性预防策略的必要性，特别是针对具有不健康生活方式因素的轮班工作者。
